TREATMENT OF 23 PATIENTS WITH ADVANCED GASTRIC CANCER BY INTRAVENOUSLY TRANSFER OF AUTOLOG

TREATMENT OF 23 PATIENTS WITH ADVANCED GASTRIC CANCER BY INTRAVENOUSLY TRANSFER

OF AUTOLOGOUS TUMOR-INFILTRATING LYMPHOCYTES COMBINED WITH rIL-2

许祥裕; 徐立春; 丁树标; 吴明生; 唐治华; 伏文钧; 倪庆

【期刊名称】《《中国医学科学杂志：英文版》》 【年(卷),期】1995(010)003

【摘要】Tumot-infiltratiug lymphocytes (TIL) isolated from metastatic lymph nodes in patients with nonoperable advanced gastric cancer were induced to become LAK-like cytotoxic activity of TIL after in vitro culture with rlL-2.Twenty-three patients with advanced gastric cancer were tratd by intravenously transfer of autologous TIL combined with rlL-2.The tumor focus disappeared (complete remission,CR) in 3 patients (13.0%) and significantly decreased (partial remission,PR) in 5 patients (21.7%).Fifteen patients did not respond to the treatment.The amount of soluable IL-2 receptor in serum was significantly decreased after treatment,the cytotoxicity of NK cells and OT test were significantly increased.No significant difference in CD4/CD8 was found between before and after treatment.No serious side effect was obseved in the treatment.

【总页数】3页(185-187)

【关键词】白细胞介素-2; 胃癌; 进展期; 临床研究; TIL; LAK细胞

【作者】许祥裕; 徐立春; 丁树标; 吴明生; 唐治华; 伏文钧; 倪庆 【

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MilitaryMedicalInstitute

NanjingMilitaryArea

Nanjing210002; YangzhouMedicalCollege Jiangsu225001 【正文语种】中文 【中图分类】R735.2 【文献来源】

https://www.zhangqiaokeyan.com/academic-journal-cn_chinese-medical-sciences-journal_thesis/0201276408612.html 【相关文献】

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