A short-term study of corneal collagen cross-linking with hypo-osmolar riboflavin solution

A short-term study of corneal collagen cross-linking with hypo-osmolar riboflavin solution in

keratoconic corneas

Shao-Feng;Gu;Zhao-Shan;Fan;Li-Hua;Wang;Xiang-Chen;Tao;Yong;Zhang;Chun-Qin;Wang;Ya;Wang;Guo-Ying;Mu;

【期刊名称】《国际眼科杂志：英文版》 【年(卷),期】2015(000)001

【摘要】AIM: To report the 3mo outcomes of collagen crosslinking(CXL) with a hypo-osmolar riboflavin in thin corneas with the thinnest thickness less than 400 μm without epithelium.METHODS: Eight eyes in 6 patients with age 26.2±4.8y were included in the study. All patients underwent CXL using a hypo-osmolar riboflavin solution after its de-epithelization. Best corrected visual acuity, manifest refraction, the thinnest corneal thickness, and endothelial cell density were evaluated before and 3mo after the procedure.RESULTS: The mean thinnest thickness of the cornea was 408.5 ±29.0 μm before treatment and reduced to369.8 ±24.8 μm after the removal of epithelium. With the application of the hypo-osmolar riboflavin solution, the thickness increased to 445.0 ±26.5 μm before CXL and recover to 412.5 ±22.7 μm at 3mo after treatment, P =0.659). Before surgery, the mean K-value of the apex of the keratoconus corneas was 57.6 ±4.0 diopters, and slightly decreased(54.7±4.9 diopters) after surgery(P =0.085). Mean best-