不同剂量瑞舒伐他汀对老年糖尿病患者颈动脉粥样硬化的
影响
郭远;宝辉;李卫;康丽萍;赵红薇;王宏宇
【期刊名称】《中国新药杂志》 【年(卷),期】2011(020)021
【摘要】目的:探讨不同剂量瑞舒伐他汀对老年糖尿病患者动脉硬化的影响.方法:选取血糖控制良好的老年糖尿病患者92例(糖尿病组)和老年糖耐量正常者52例(NGT组),测定并比较颈动脉内中膜厚度(IMT)、斑块及内皮功能(EDD)等.在常规降糖基础上,将糖尿病患者按服用瑞舒伐他汀的剂量分为3组:常规组(10 mg?d-1)、强化组(20 mg?d-1)和对照组(未服用他汀类药物),观察12个月后3组患者颈动脉硬化的变化.结果:与NGT组比较,糖尿病组IMT及斑块检出率明显升高.治疗后常规组IMT无明显变化,强化组明显变薄；治疗后常规组斑块面积显著减少,强化组减少更明显(P＜0.05).对照组上述指标在治疗前后无明显变化.结论:在常规降糖基础上,瑞舒伐他汀可延缓或逆转老年糖尿病患者颈动脉硬化,这可能与其调脂、抑制炎症反应及改善内皮功能有关.%Objective; To investigate the effect of rosuvastatin on carotid atherosclerosis in elderly patients with diabetes mellitus (DM). Methods; Totally 92 DM patients with glycemic control and 52 elderly subjects with normal glucose tolerance ( NGT) were compared. DM patients with 10 and 20 mg'd -1 rosuvastatin for 12 months in addition to usual hypoglycemia medications, or with usual hypoglycemia medications alone (control group). The carotid intima-media thickness (IMT), carotid plaque,
endothelium-dependent dilation (EDD), serum levels of lipid, and high-sensitive C reaction protein (HsCRP) were measured and analyzed. Results; Carotid IMT and atherosclerotic plaque were higher in DM group than in NGT group. Compared with pre-treatment, IMT did not change in 10 mg'd-1 group and significantly decreased in 20 mg'd-1 group after treatment. Plaque area significantly decreased in 10 mg'd-1 group and decreased further in 20 mg'd-1 group after treatment (P <0.05). There was no significant difference in the two carotid parameters between pre-treatment and post-treatment. Furthermore, the change in IMT was correlated with the change in HsCRP or EDD. Conclusion; Rosuvastatin can retard or decrease carotid atherosclerosis in elderly DM patients.
【总页数】5页(2123-2126,2138)
【关键词】老年;糖尿病;瑞舒伐他汀;内中膜厚度;斑块 【作者】郭远;宝辉;李卫;康丽萍;赵红薇;王宏宇
【作者单位】北京大学人民医院老年科,北京100044;北京大学人民医院老年科,北京100044;北京大学人民医院老年科,北京100044;北京大学人民医院老年科,北京100044;北京大学人民医院血管中心,北京100044;北京大学人民医院血管中心,北京100044 【正文语种】中文 【中图分类】R977.1 【文献来源】
https://www.zhangqiaokeyan.com/academic-journal-cn_chinese-journal-new-drugs_thesis/0201242183085.html 【相关文献】
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不同剂量瑞舒伐他汀对老年糖尿病患者颈动脉粥样硬化的影响
