The Effect of Interleukin-6 on the Proliferation of Prostate Cancer Cells in Vitro and the

The Effect of Interleukin-6 on the Proliferation of Prostate Cancer Cells in Vitro and the Modulation

of This Procedure

XING;Yifei;XIAO;Yajun;ZHANG;Qijun;LU;Gongcheng

【期刊名称】《华中科技大学学报：医学英德文版》 【年(卷),期】2001(000)003

【摘要】The role of interleukin-6 (IL-6) in the growth of an androgen-independent prostate cancer cell line (PC-3m) was defined and the effect of dexamethasone, which was previously shown to modulate IL-6/IL-6 receptor (IL-6R) on this procedure was investigated. By using a pretty sensitive and specific enzyme immunoassay (ELISA), it was found that PC-3m produced certain IL-6, but there was no difference in IL-6 secretion between the group with or without dexamethasone treatment. It was also found that PC-3m cells could not be stimulated to grow by exogenous IL-6 (P＞0.05), while it could be inhibited to grow by anti-IL-6 monoclonal antibody and dexamethasone with a dose-dependent fashion. Our observation indicated that IL-6 acted as an autocrine growth factor for PC-3m, and dexamethasone could inhibit cell proliferation by a mechanism independent of its effect on IL-6 mRNA expression.

【总页数】4页(P.225-227,208)

【关键词】interleukin-6;prostate;cancer;dexamethasone;crystal;violet

【作者】XING;Yifei;XIAO;Yajun;ZHANG;Qijun;LU;Gongcheng 【

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Department;of;Urology,;Xiehe;Hospital,;Tongji;Medical;College,;Huazhong;University;of;Science;and;Technology,Wuhan;430022;Department;of;Urology,;Xiehe;Hospital,;Tongji;Medical;College,;Huazhong;University;of;Science;and;Technology,Wuhan;430022;Department;of;Urology,;Xiehe;Hospital,;Tongji;Medical;College,;Huazhong;University;of;Science;and;Technology,Wuhan;430022;Department;of;Urology,;Xiehe;Hospital,;Tongji;Medical;College,;Huazhong;University;of;Science;and;Technology,Wuhan;430022

【正文语种】英文 【中图分类】R 【文献来源】

https://www.zhangqiaokeyan.com/academic-journal-cn_journal-huazhong-university-science-technology-medical-english-german-edition_thesis/0201268455776.html 【相关文献】

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