DNA自组装技术的研究进展及难点
杨静;张成
【期刊名称】《计算机学报》 【年(卷),期】2008(031)012
【摘要】DNA self-assembly,widely developed in the fields of DNA computing and nanotechn-ology,is related to the development of DNA computer.How DNA molecules assemble has be-come the focus of scientific fields.This paper mainly discusses the DNA self-assembly technology of one-dimension,two-dimension and three-dimension structure.DNA self-assembly units are divided into three types: a long DNA single-strand,several short DNA single-strands and prima-ry units of DNA self-assembly.In the meantime,the principle and research progress of DNA self-assembly are discussed.On the other hand,the main obstacles and solutions of the application on DNA computing are also analyzed.Firstly,coding is the most difficult problem,as it decides whether the experiment can be implemented.Secondly,the assembled angle between DNA sin-gle-strands and the connections among motifs.In addition,from the experiment operation,whether the self-assembly structure can be achieved is decided by the concentration proportion of each DNA single-strand and the anneal temperature.With the rapid developing of science and technology and combination of multi-disciplinary science,DNA self-assembly has become the im-
DNA自组装技术的研究进展及难点
