Fermented Barley Extracts with Lactobacillus plantarum dy-1 Rich in Vanillic Acid Modulate

Fermented Barley Extracts with Lactobacillus plantarum dy-1 Rich in Vanillic Acid Modulate Glucose Consumption in Human HepG2 Cells

ZHANG Jia Yan;XIAO Xiang;DONG Ying;ZHOU Xing Hua

【期刊名称】《生物医学与环境科学（英文版）》 【年(卷),期】2018(031)009

【摘要】Objective To investigate the effect of fermented barley extracts with Lactobadllus plantarum dy-1 (LFBE) for modulating glucose consumption in HepG2 cells via miR-212 regulation.Methods Hepatocellular

carcinoma

(HepG2)

cells

were

treated

with

palmitate.After 12 h,palmitate-induced HepG2 cells were treated with LFBE

and

its

main

components.Changes cytokine

secretion,and

in

glucose

consumption,proinflammatory miRNA-212

expression in HepG2 cells was observed.Results Treatment with LFBE rich in vanillic acid (VA) increased glucose consumption and reduced proinflammatory cytokine secretion in HepG2 cells.LFBE and VA normalized the upregulation of miR-212,which led to the upregulation of dual-specificity phosphatase-9 (DUSP9),a direct target of miR-212,at both protein and mRNA levels.Downregulation of miR-212 markedly increased glucose consumption and reduced proinflammatory cytokine secretion by enhancing DUSP9 expression.Conclusion The results showed the benefit of LFBE and miR-212 downregulation in modulating

glucose consumption and reducing proinflammatory cytokine secretion by targeting DUSP9.VA in LFBE was a strong regulator of palmitate-induced abnormal glucose consumption in HepG2 cells and can be a primary mediator.

【总页数】10页(667-676) 【关键词】

【作者】ZHANG Jia Yan;XIAO Xiang;DONG Ying;ZHOU Xing Hua

【作者单位】School of Food and Biological Engineering, Jiangsu University, Zhenjiang 212013, Jiangsu, China;School of Food and Biological Engineering, Jiangsu University, Zhenjiang 212013, Jiangsu, China;School of Food and Biological Engineering, Jiangsu University, Zhenjiang 212013, Jiangsu, China;School of Food and Biological Engineering, Jiangsu University, Zhenjiang 212013, Jiangsu, China 【正文语种】英文 【中图分类】 【文献来源】

https://www.zhangqiaokeyan.com/academic-journal-cn_biomedical-environmental-sciences_thesis/0201270414783.html 【相关文献】

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