多孔方解石相碳酸钙微球的自组装合成及口腔修复应用
马明;颜燕宏;漆超;祁胜财;陈世雄;尚光伟;汪饶饶;陈航榕
【期刊名称】《中国科学：材料科学（英文）》 【年(卷),期】2017(060)006
【摘要】多孔碳酸钙微球的弱水溶液稳定性和低再矿化速率限制了其在生物医药领域的应用.为了解决该问题,本论文通过“气体扩散-陈化”两步策略制备了具有大孔结构和方解石相的碳酸钙微球材料.该合成策略反应条件温和,同时不需要使用模板剂和晶型导向剂,能够确保微球产物的生物安全性.所制备的碳酸钙微球可以吸附大量的免疫球蛋白IgY,并表现出增强抑制口腔变形链球菌的能力.此外,研究显示该微球可以在水溶液中保持较高的结构稳定性,而在人体体液和唾液环境中快速再矿化并转变成羟基磷灰石结构,对牙本质小管具有较佳的封闭效果,为其用于治疗牙本质过敏症提供了依据.%Biomedical applications of porous calcium carbonate (CaCO3) microspheres have been mainly restricted by their aqueous instability and low remineralization rate.To overcome these obstacles,a novel symmetry-breaking assembled porous calcite microsphere (PCMS) was constructed in an ethanol/water mixed system using a two-step vapor-diffusion/aging crystallization strategy.In contrast
to
the
conventional
additive-induced
crystallization
method,the present strategy was performed under mild conditions and was free from any foreign additives,thus avoiding the potential contamination of the final product.Meanwhile,the prepared PCMSs were characterized by their highly uniform spherical morphology and large
open pores,which are fa vorable for large protein delivery.An antimicrobial study of immunoglobulin Y (IgY)-loaded PCMSs revealed excellent antimicrobial activity against Streptococcus mutans.More importantly,they showed surprisingly rapid transformation to bone minerals in physiological medium.Evaluation of the in vitro efficacy of PCMSs in dentinal tubule occlusion demonstrated their powerful potential to serve as a catalyst in the repair of dental hard tissue.Therefore,the developed PCMSs show great promise as multifunctional biomaterials for dental treatment applications. 【总页数】13页(516-528) 【关键词】
【作者】马明;颜燕宏;漆超;祁胜财;陈世雄;尚光伟;汪饶饶;陈航榕 【作者单位】;;;;;;; 【正文语种】中文 【中图分类】 【文献来源】
https://www.zhangqiaokeyan.com/academic-journal-cn_chinese-science-materials-science-english_thesis/0201263838574.html 【相关文献】
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2.碳酸钙为模板微波水热合成碳酸羟基磷灰石微球 [J], 朱万华; 张群; 汪小红;
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多孔方解石相碳酸钙微球的自组装合成及口腔修复应用
