Product Data?SheetBimosiamoseCat. No.:CAS No.:分?式:分?量:作?靶点:作?通路:储存?式:HY-106139187269-40-5C??H??O??862.91OthersOthersPowderIn solvent-20°C4°C-80°C-20°C3 years2 years6 months1 monthInhibitors?Agonists?Screening Libraries溶解性数据体外实验DMSO : 125 mg/mL (144.86 mM; Need ultrasonic)0.1 M NaOH : 25 mg/mL (28.97 mM; ultrasonic and adjust pH to 10 with NaOH)Mass1 mg5 mg10 mgSolventConcentration制备储备液1 mM5 mM10 mM1.1589 mL0.2318 mL0.1159 mL5.7943 mL1.1589 mL0.5794 mL11.5887 mL2.3177 mL1.1589 mL请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；?旦配成溶液，请分装保存，避免反复冻融造成的产品失效。储备液的保存?式和期限：-80°C, 6 months; -20°C, 1 month。-80°C 储存时，请在 6 个?内使?，-20°C 储存时，请在 1 个?内使?。BIOLOGICAL ACTIVITY?物活性Bimosiamose (TBC-1269) 是?种?寡糖泛-selectin 拮抗剂，对 E-selectin，P-selectin 和 L-selectin 的 IC50 分别为 88 μM，20 μM 和 86μM。Bimosiamose 具有抗炎作?[1]。IC?? & Target体外研究IC50: 88 μM (E-selectin), 20 μM (P-selectin), 86 μM (L-selectin)[1]Bimosiamose (TBC-1269) operates by inhibiting neutrophil recruitment to the site of inflammation through blocking the initial rolling phase of recruitment. Bimosiamose (TBC-1269) inhibits cell recruitment and does not possess any cytotoxic effect on neutrophils[1].体内研究Bimosiamose (TBC-1269; 25 mg/kg; intravenous injection; Sprague-Dawley rats) treatment shows a significant increase in survival. Best overall survival, 70%, is observed when TBC-1269 is administered 15 minutes before Page 1 of 2
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reperfusion, and also shows a marked decrease in liver enzyme levels at 6 hours after reperfusion. Neutrophil migration is also significantly ameliorated (81%). The histologic damage scores is also improved[1].Animal Model:Dosage:Administration:Result:Sprague-Dawley rats (200-225g) with ischemia and reperfusion (I/R)[1]25 mg/kgIntravenous injectionShowed a significant increase in survival compared with controls.REFERENCES[1].?Palma-Vargas JM, et al. Small-molecule selectin inhibitor protects against liver inflammatory response after ischemia and reperfusion. J Am Coll Surg. 1997 Oct;185(4):365-72.McePdfHeightCaution: Product has not been fully validated for medical applications. For research use only.
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