Luminal B型局部晚期乳腺癌新辅助化疗疗效预测基因的
研究
王梅;汪海新;胡薇;熊安稳;吴梅红;李永梅;王薇;王雅杰
【期刊名称】《临床肿瘤学杂志》 【年(卷),期】2014(000)005
【摘要】Objective To screen prognostic genes for neoadjuvant chemotherapy in patients with locally advanced breast cancer of luminal B type. Methods Ten locally advanced breast cancer patients of luminal B
type
were
underwent
DA
regimen
as
neoadjuvant
chemotherapy( docetaxel 75mg/m2 iv, d1;epirubicin 80 mg/m2 iv, d1 , 3 weeks as a cycle for 4 cycles) . Based on RECIST1?1 standard, 10 patients were divided into pathological complete remission( pCR) group( n=3) and non-pathological complete remission( npCR) group ( n=7) . GeneChip human genome was used to screen prognostic genes for neoadjuvant chemotherapy in 10 luminal B breast cancer pa-tients. Florescence quantitative PCR was conducted to confirm the different gene expression. Results Compared with npCR patients, 231 genes expression were up-regulated, 195 genes expression were down-regulated in tumor samples of pCR patients;Compared with peri-tumor tissues, 357 genes expression were up-regulated and 544 genes expression were down-regulated in tumor samples of pCR patients. Compared with peri-tumor tissues, 143 genes expression were up-
Luminal B型局部晚期乳腺癌新辅助化疗疗效预测基因的研究
