Effect of acidity of drugs on the prediction of human oral absorption by biopartitioning m

Effect of acidity of drugs on the prediction of human oral absorption by biopartitioning micellar

chromatography

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【期刊名称】《药物分析学报：英文版》 【年(卷),期】2010(000)004

【摘要】Biopartitioning micellar chromatography(BMC)is a potentially high throughput and low cost alternative for in vitro prediction of drug absorption,which can mimic the drug partitioning process in biological systems.In this paper,a data set of 56 compounds representing acidic,basic,neutral and amphoteric drugs from various structure classes with human oral absorption(HOA)data available were employed to show the effect of acidity of drugs in oral absorption prediction.HOA was reciprocally correlated to the nega... 【总页数】8页(P.233-240) 【关键词】 【作者】无 【作者单位】 【正文语种】英文 【中图分类】R91 【相关文献】

1.Effect of acidity of drugs on the prediction of human oral absorption