Indirubin-3′-monoxime suppresses amyloid-beta-induced apoptosis by inhibiting tau hyperp
Indirubin-3′-monoxime suppresses amyloid-beta-induced apoptosis by inhibiting tau
hyperphosphorylation
Shu-gang Zhang;Xiao-shan Wang;Ying-dong Zhang;Qing Di;Jing-ping Shi;Min Qian;Li-gang Xu;Xing-jian Lin;Jie Lu
【期刊名称】《中国神经再生研究（英文版）》 【年(卷),期】2016(011)006
【摘要】Indirubin-3′-monoxime is an effective inhibitor of cyclin-dependent protein kinases, and may play an obligate role in neuronal apopto-sis in Alzheimer’s disease. Here, we found that indirubin-3′-monoxime improved the morphology and increased the survival rate of SH-SY5Y cells exposed to amyloid-beta 25–35 (Aβ25–35), and also suppressed apoptosis by reducing tau phosphorylation at Ser199 and Thr205. Furthermore, indirubin-3′-monoxime inhibited phosphorylation of glycogen synthase kinase-3β (GSK-3β). Our results suggest that in-dirubin-3′-monoxime suppressing
tau
reduced
Aβ25–35-induced
a
apoptosis
by
hyperphosphorylationvia GSK-3β-mediated
mechanism. Indirubin-3′-monoxime is a promising drug candidate for Alzheimer’s disease. 【总页数】6页(988-993) 【关键词】
【作者】Shu-gang Zhang;Xiao-shan Wang;Ying-dong Zhang;Qing
Di;Jing-ping Shi;Min Qian;Li-gang Xu;Xing-jian Lin;Jie Lu
【作者单位】Department of Neurology, Afifliated Nanjing Brain Hospital, Nanjing
Medical
University,
Nanjing,
Jiangsu
Province,
China;Department of Neurology, Afifliated Nanjing Brain Hospital, Nanjing
Medical
University,
Nanjing,
Jiangsu
Province,
China;Department of Neurology, Afifliated Nanjing Brain Hospital, Nanjing
Medical
University,
Nanjing,
Jiangsu
Province,
China;Department of Neurology, Afifliated Nanjing Brain Hospital, Nanjing
Medical
University,
Nanjing,
Jiangsu
Province,
China;Department of Neurology, Afifliated Nanjing Brain Hospital, Nanjing
Medical
University,
Nanjing,
Jiangsu
Province,
China;Department of Neurology, Afifliated Nanjing Brain Hospital, Nanjing
Medical
University,
Nanjing,
Jiangsu
Province,
China;Department of Neurology, Afifliated Nanjing Brain Hospital, Nanjing
Medical
University,
Nanjing,
Jiangsu
Province,
China;Department of Neurology, Afifliated Nanjing Brain Hospital, Nanjing
Medical
University,
Nanjing,
Jiangsu
Province,
China;Department of Neurology, Afifliated Nanjing Brain Hospital, Nanjing Medical University, Nanjing, Jiangsu Province, China 【正文语种】英文 【中图分类】 【相关文献】
1.Cyanidin suppresses amyloid beta-induced neurotoxicity by inhibiting reactive oxygen species-mediated DNA damage and apoptosis in PC12 cells [J], Yi Wang; Nam Chun Cho; Xiao-ting Fu; Da-wei Li; Kun Wang; Xin-zhi Wang; Yuan Li; Bao-liang Sun; Xiao-yi Yang; Zun-cheng Zheng 2.Hydrogen sulfide inhibits beta-amyloid peptide-induced apoptosis in PC12 cells and the underlying mechanisms [J], Xiuqin Chen; Jingtian Li; Jinhui Zou; Bailing Li; Meng Wang 3.Endogenous
overproduction
of
beta-amyloid
induces
tau
hyperphosphorylation and decreases the solubility of tau in N2a cells. [J], Wang; YP; Wang; XC; Tian; Q; Yang; Y; Zhang; Q; Zhang; JY; Zhallg; YC; Wang; ZF; Wang; Q; Li; H; Wang; JZ
4.Agglutinin isolated from Arisema heterophyllum Blume induces apoptosis and autophagy in A549 cells through inhibiting PI3K/Akt pathway and inducing ER stress [J], FENG Li-Xing; SUN Peng; MI Tian; LIU Miao; LIU Wang; YAO Si; CAO Yi-Min
5.Nitric oxide inhalation inhibits inducible nitric oxide synthase but not nitrotyrosine formation and cell apoptosis in rat lungs with meconium-induced injury [J], Mei-ping LU; Li-zhong DU; Wei-zhong GU; Xiang-xiang CHEN
以上内容为文献基本信息，获取文献全文请下载
Indirubin-3′-monoxime suppresses amyloid-beta-induced apoptosis by inhibiting tau hyperp
