不同类型痴呆患者阿尔茨海默病相关神经丝蛋白水平和嗅觉功能差异的比较

不同类型痴呆患者阿尔茨海默病相关神经丝蛋白水平和嗅

觉功能差异的比较

邹永明;田志岩;张惠红;包翠萍;周玉颖

【期刊名称】《中华老年医学杂志》 【年(卷),期】2018(037)007

【摘要】Objective To explore the diagnostic value of Alzheimer-associated neuronal thread protein(AD7C-NTP)and olfactory function in the differentiation of three types of dementia,and to evaluate their clinical application value.Methods Mini-Mental State Examination (MMSE)and Montreal Cognitive Assessment(MoCA)were applied to evaluate

cognitive

function

of

all

subjects

with

Alzheimer

disease(AD),frontotemporal dementia (FTLD),or mixed dementia

(MD).Enzyme-linked immunosorbent assay(ELISA)was used to detect the expression levels of AD7c-NTP in urine.T&T test method was applied to detect the olfactory function.Spearman rank correlation was used to evaluate the correlation of urine AD7c NTP with MMSE and MoCA scores.Results There was no significant difference in the demographic profile (except age)among three types of dementia of AD,FTLD and MD(F =4.05,P =0.02).Among the three dementia groups,the mean age of the MD group was highest.The statistically significant difference in MMSE scores was found among the three groups(F 3.79,P=0.03),while there was no significant difference