Evaluation of the in vivo effect of ivermectin on Schistosoma mansoni in experimentally-in

Evaluation of the in vivo effect of ivermectin on Schistosoma mansoni in experimentally-infected

mice

Amira Taman;Samar El-Beshbishi;Nora El-Tantawy;Amira El-Hawary;Manar Azab

【期刊名称】《海岸生命医学杂志（英文版）》 【年(卷),期】2014(000)010 【

摘

要

】

Objective:?To?evaluate?the?effect?of?ivermectin?on?mice?experimentally?infected?with?Schistosomamansoni.?Methods:?Ivermectin?was?given?to?mice?42?days?p.o.?in?two?treatment?regimens:?a?single?dose?of?25?mg/kg?or?the?same?dose?for?two?consecutive?days.Results:?In?both?regimens,?there?were?significant?reductions?in?female?worms,?hepatic?tissue?egg?count?and?early?immature?ova,?in?addition?to?significant?reductions?in?the?count?and?size?of?hepatic?granuloma.?The?same?dose?for?two?consecutive?days?resulted?in?significant?reductions?in?male,?total?worms,?and?intestinal?tissue?egg?load.?In?both?regimens,?scanning?electron?microscopy?revealed?tegumental?alternations?as?bleb?formation,?erosion?and?necrosis?more?evident?with?the?double?dose.?In?addition,?high?dose?showed?extensive?erosions?of?male?worms?with?destruction?of?the?gynaecophoric?canal.??In?females,?marked?destruction?of?the?tegumental?surface?was?extending?to?both?ventral?and?oral?suckers.Conclusions:?Ivermectin?has?promising?anti-schistosomal?effects.?However,?further?research?is?needed?to?test?the?effec