α-黑素细胞刺激素对EAE豚鼠外周血单个核细胞分泌IL-4、
IFN-γ水平的影响
李玉竹;于周;吕志宇;李作孝
【期刊名称】《医学信息》 【年(卷),期】2014(000)001
【摘要】Objective:To investigate the immunological mechanism underlying
alpha-melanocyte-stimulating
hormone
(alpha-MSH)
against experimental al ergic encephalomyelitis (EAE) by studying the ef ect of alpha-MSH on the release of IL-4,IFN-γof guinea pigs suf ering from EAE. Methods:Forty female Guinea pigs were assigned randomly to four groups:the normal group, the EAE control group, the low dose treated EAE group and the high dose treated EAE group. intervention have been done from the mould to fastigium seven days to the end. The neurological disorder change of each groups were compared;the levels of IL-4 and IFN-γ were detected by ELISA method. Results: The level of neurological disorder in the high dose treated EAE group and the low dose treated EAE group were lower than that of the EAE control group (P<0.01,P<0.05). The high dose treated EAE group was the lowest (P<0.05). The levels of IFN-γ from PBMC in the high dose treated EAE group and low dose treated group were significantly lower than that in the EAE control group (P<0.01,P<0.01),The levels of IL-4 from PBMC were the opposite (P<0.01,P<0.01), But the significantly changes exsist
α-黑素细胞刺激素对EAE豚鼠外周血单个核细胞分泌IL-4、IFN-γ水平的影响
