Two New Ursane-type Triterpenoid Glycosides from Ilex Cornuta

Two New Ursane-type Triterpenoid Glycosides

from Ilex Cornuta

Hai-xia ZHAN[1];Juan LI[2];Han-li RUAN[1];Peng ZHANG[1];Hui-fang PI[1];

【期刊名称】《当代医学科学(英文)》 【年(卷),期】2018(038)006

【摘要】Ilex cornuta (1.cornuta)is a traditional Chinese medicine (TCM)that has been used in clinical practice for hundreds of years.In order to provide more information about the chemical basis of its pharmacological effects,phytochemical investigation on the roots of L cornuta was conducted in this study.The roots of the plant were firstly extracted with 95% EtOH,and then the crude was partitioned with petroleum ether,EtOAc and n-butyl alcohol.Different chromatographies were employed to isolate the crude step by step and the crude was further

purified by

semipreparative

high

performance

liquid

chromatography (HPLC).As a result,two new triterpenoid saponins (1,2),together with 12 known compounds (3-14),were isolated from the roots of I. cornuta.Their structures were determined based on nuclear magnetic resonance (NMR),mass spectrum (MS)technologies,chemical reactions as well as gas chromatography (GC).Compounds 4,6,8,11,12 and 13 were isolated from this genus for the first time.The structures of compounds 1 and 2 were determined as 3β-O-α-D-xylopyranosyl-(1→3)-α-L-2-O-acetylarabinopyranosyl-(1→2)-β-D glucopyranosyl-23-

hydroxyl-20α(H)-urs-12-en-28-oic acid 28-O-β-D-glucopyranosyl ester (1)and 3β-O-α-D-xylopyranosly-(1→3)-α-L-2-O-acetylarabinopyranosyl-(1→2)-β-D-glucopyranosyl-19α,23-dihydroxyl-20α(H)-urs-12-en-28-oic acid 28-O-β-D-glucopyranosyl ester(2). 【总页数】6页(P.976-981)

【关键词】Ilex cornuta;aquifoliaceae;triterpenoids

【作者】Hai-xia ZHAN[1];Juan LI[2];Han-li RUAN[1];Peng ZHANG[1];Hui-fang PI[1];

【作者单位】[1]School of Pharmacy,Tongji Medical College,Huazhong University of Seience and Technology,Hubei Key Laboratory of Natural Medicinal

Chemistry

and

Resource

Evaluation,Wuhan

430030,China;[2]Department of Pharmacy,Tongji Hospital,Tongji Medical College,Huazhong University of Science and Technology,Wuhan 430030,China;[1]School of Pharmacy,Tongji Medical College,Huazhong University of Seience and Technology,Hubei Key Laboratory of Natural Medicinal

Chemistry

and

Resource

Evaluation,Wuhan

430030,China;[1]School of Pharmacy,Tongji Medical College,Huazhong University of Seience and Technology,Hubei Key Laboratory of Natural Medicinal

Chemistry

and

Resource

Evaluation,Wuhan

430030,China;[1]School of Pharmacy,Tongji Medical College,Huazhong University of Seience and Technology,Hubei Key Laboratory of Natural Medicinal Chemistry and Resource Evaluation,Wuhan 430030,China;

【正文语种】英文 【中图分类】R 【文献来源】

https://www.zhangqiaokeyan.com/academic-journal-cn_current-medical-science_thesis/0201270128408.html 【相关文献】

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