Continuous Low-dose-rate Irradiation of Iodine-125 Seeds Inhibiting Perineural Invasion in

Continuous Low-dose-rate Irradiation of Iodine-125 Seeds Inhibiting Perineural Invasion in

Pancreatic Cancer

Zheng Lu;Teng-Hui Dong;Pei-Ren Si;Wei Shen;Yi-Liang Bi;Min Min;Xin Chen

【期刊名称】《中华医学杂志（英文版）》 【年(卷),期】2016(129)020

【摘要】Background:Perineural invasion (PNI) is a histopathological characteristic of pancreatic cancer (PanCa).The aim of this study was to observe the treatment effect of continuous low-dose-rate (CLDR) irradiation to PNI and assess the PNI-related pain relief caused by iodine-125 (125I) seed implantation.Methods:The in vitro PNI model established by co-culture with dorsal root ganglion (DRG) and cancer cells was interfered under 2 and 4 Gy of 125I seeds CLDR irradiation.The orthotopic models of PNI were established,and 125I seeds were implanted in tumor.The PNI-related molecules were analyzed.In 30 patients with panCa,the pain relief was assessed using a visual analog scale (VAS).Pain intensity was measured before and 1 week,2 weeks,and 1,3,and 6 months after 125I seed implantation.Results:The co-culture of DRG and PanCa cells could promote the growth of PanCa cells and DRG neurites.In co-culture groups,the increased number of DRG neurites and pancreatic cells in radiation group was significantly less.In orthotopic models,the PNI-positive rate in radiation and control group was 3/11