新辅助化疗对大肠癌患者CD44v6,p27蛋白表达与预后的
影响
孙秀梅;高峰;李贵新;刘康
【期刊名称】《中国新药杂志》 【年(卷),期】2011(020)017
【摘要】Objective: To investigate'the influence of new neoadjuvant chemotherapy on the prognosis and the protein expression of CD44v6 and p27 in patients with colorectal cancinoma. Methods; Totally 78 patients with colorectal cancinoma underwent surgery were enrolled from January 2007 to January 2010, including 39 males and 39 females. We divided patients into group A (Ⅰ, ⅡA, n =39) and group B (Ⅱg, Ⅲ , Ⅳ , n =39) according to clinical stages. Immunohistochemistry was performed to detect the expression of CD44v6 and p27 before and after neoadjuvant chemotherapy. The side effects after neoadjuvant chemotherapy were recorded according to Common Terminology Criteria for Adverse Events, edition 3 (CTCAE3 ). Results; Expression of CD44v6 and p27 in patients of group A had no statistically significant difference before and after neoadjuvant chemotherapy (P ＞0.05). Positive expression ratios of CD44v6 and p27 in patients of group B were 76. 92% and 41.03% before neoadjuvant chemotherapy, and 35.09% and 79.49% after neoadjuvant chemotherapy. There was significant difference before and after neoadjuvant chemotherapy ( P ＜ 0.01).
新辅助化疗对大肠癌患者CD44v6,p27蛋白表达与预后的影响
