牙周非手术治疗对重度慢性牙周炎患者龈沟液中MM P-8
和TIM P-1水平的影响
詹暶;林燕;陈梅芳;李艳芬;闫福华
【期刊名称】《福建医科大学学报》 【年(卷),期】2015(000)006
【摘要】目的:评价牙周非手术治疗对重度慢性牙周炎患牙龈沟液(GCF)中基质金属蛋白酶-8(MMP-8)及其组织抑制剂-1(T IM P-1)水平的影响。方法选取20颗重度牙周炎患牙,牙周非手术治疗前后检查菌斑指数(PLI)、牙周袋深度(PD)、出血指数(BI)、附着丧失(AL),收集 GCF ,采用酶联免疫吸附法(ELISA)检测GCF中MMP-8和TIMP-1的含量。结果牙周非手术治疗能显著改善 PLI、PD、BI和GCF的量(P<0.01)以及AL (P<0.05)。GCF中MMP-8和TIMP-1的水平在治疗前后无明显变化;除TIMP-1与治疗后PLI呈正相关关系外(P<0.05),MMP-8和TIMP-1与其他临床指标均无显著相关性。结论牙周非手术治疗能有效改善重度慢性牙周炎的临床指标,但不能改变GCF中MMP-8和TIMP-1的水平。%Objective The study of the influence of nonsurgical treatment was determined on a-mounts of matrix
metalloproteinases-8(MMP-8)
and
tissue
inhibitiors
of
metalloproteinases-1(TIMP-1) in gingival crevicular fluid(GCF) from teeth with advanced chronic periodontitis . Methord The study con-sisted of 20 teeth with advanced chronic periodontitis from 7 chronic periodontitis patients . The amounts of MMP-8 and TIMP-1 in GCF were assayed by ELISA . Patients were treated by nonsurgical treatment and
牙周非手术治疗对重度慢性牙周炎患者龈沟液中MM P-8和TIM P-1水平的影响
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