PROCESS FOR PREPARING TETRAHYDROPYRIDO£2,3-3|PYRIMIDINE DERIVATIVES
申请(专利)号: KR19870005798
专利号: KR950004894B1 主分类号: C07D471/04 申请权利人: THE TRUSTEES
OF PRINCETON UNIVERSITY
申请日: 1987-06-05 公开公告日: 1995-05-15
分类号: C07D471/04 发明设计人: TAYLOR, EDWARD
C.;
BEARDSLEY, GEORGE P.; SHIH, CHUAN; PLETCHER, STEPHEN R. 申请国代码: KR
优先权: 19860606 US
871,539
摘 要 附 图:
公开国代码: KR 优先权国家: US
摘 要:
The diastereoisomeric forms of N-(4-[2-(2-amino-4-hydroxy-5,6,7,8-tetrahydropyrido[2,3-d] -pyrimidin-6-yl)ethyl]benzoyl)-L-glutamic acid are antineoplastic agents. The compounds are prepared by separation of the diastereoisomeric form of the
correspondingly protected glutamic derivatives and hydrolytic or
hydrogenolytic removal of carboxylic acid and/or amino protecting groups. 主权项:
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