VEGFR、ERCC1mRNA表达量对肺癌患者预后的临床意
义
许鸿雁;赵忠民;王文慧;庄庆媛
【期刊名称】《中国社区医师》 【年(卷),期】2016(032)016
【摘要】Objective:To study the effect of VEGFR and ERCC1mRNA expression on the prognosis of patients with lung cancer. Methods:40 patients with non small cell lung cancer whom completed surgical resection were selected,and their postoperative pathological samples were detected to measure the expression of VEGFR and ERCC1,and then we analyzed the relationship between the expression of VEGFR and ERCC1 and the prognosis.Results:There were 25 cases with positive lung cancer VEGFR mRNA expression,in which there 13 cases mergered with ERCC1 expression positive,among those 13 cases,there were 12 cases(92.3%) confirmed metastasis by pathology or image,12 patients with negative ERCC1 expression,there were 8 cases(66.6%) confirmed metastasis;15 cases with negative VEGFR mRNA expression,in which 2 cases combined with positive ERCC1 expression,and 13 cases with negative ERCC1 expression,among which there 6 patients were transfered confirmed by pathology or image.Conclusion:The expression of mRNA VEGFR has significantly correlated with lymph node metastasis,differentiation degree and TNM stage of lung cancer,the
positive mRNA EGFR expression and ERCC1 expression with higher transfer rate,and the prognosis was poor.%目的：探讨VEGFR、ERCC1mRNA表达对肺癌患者预后的影响。方法：选择40例完全性手术切除的非小细胞肺癌患者，取其术后病理标本，检测VEGFR以及ERCC1表达情况，分析与患者预后的关系。结果：肺癌组织VEGFR mRNA表达阳性25例，合并ERCC1表达阳性的NSCLC患者13例，病理学或影像学证实转移12例(92.3%)，合并 ERCC1表达阴性的 NSCLC 患者12例，病理学或影像学证实转移8例(66.6%)；VEGFR mRNA 表达阴性15例，合并ERCC1表达阳性的NSCLC患者2例，合并ERCC1表达阴性的NSCLC患者13例，病理学或影像学证实转移患者6例。结论：VEGFR mRNA的表达与肺癌的淋巴结转移、分化程度及TNM分期显著相关，EGFR mRNA表达阳性合并ERCC1表达阳性者转移率较高，预后较差。 【总页数】2页(116-117)
【关键词】VEGFR;ERCC1;肺癌;预后 【作者】许鸿雁;赵忠民;王文慧;庄庆媛
【作者单位】132000吉林省吉林市肿瘤医院;132011吉林市中心医院;132011北华大学附属医院;132000吉林省吉林市肿瘤医院 【正文语种】中文 【中图分类】 【文献来源】
https://www.zhangqiaokeyan.com/academic-journal-cn_chinese-community-doctors_thesis/0201214763931.html
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VEGFR、ERCC1mRNA表达量对肺癌患者预后的临床意义
