半乳糖凝集素1在胃癌组织中的表达及其临床意义
李萍;汤东;李清国;王道荣
【期刊名称】《中华实验外科杂志》 【年(卷),期】2014(031)005
【摘要】Objective To investigate the expression of Galectin-1 in gastric cancer and their clinical significanc.Methods Streptavid-in-peroxidase (SP) immunohistochemistry was used to detect the expression of galectin-1 in 124 specimens including 124 normal tissue,124 carcinoma sides tissues,124 gastric carcinomaand.Real-time RT-PCR and Western blotting was used to detect galectin-1 expression in 124 fresh specimens of gastric carcinoma and normal gastric tissue.The survival curve was drawn by Kaplan-Meier method,and the survival rates of the patients were analyzed by Log-rank test.Results The Galectin-1 expression in cancerous tissue increased significantly compared with that in the para-cancerous tissue (P ＜ 0.01),the positive expression of galectin-1 has more recurTence and shorter survival.Conclusion Galectin-1 may be involved in the development and progression of gastric cancer,and relate to the infiltration,differentiation,lymphnode metastasis and recurrence of gastric cancer.%目的 检测半乳糖凝集素l(Galectin-1)在胃癌组织、癌旁组织、正常胃组织的表达,探讨其与胃癌发生、发展、侵袭转移及预后的关系.方法 (1)用链霉菌抗生物素蛋白-过氧化物酶(SP)免疫组织化学法检测124例临床组织标本(包括正常胃组织124例,癌旁组织
半乳糖凝集素1在胃癌组织中的表达及其临床意义
