氯沙坦对老年慢性充血性心力衰竭患者血浆NT-proBNP
水平的影响
王坤
【期刊名称】《南昌大学学报（医学版）》 【年(卷),期】2014(000)001
【摘要】Objective To investigate the effects of losartan on plasma NT-proBNP levels in eld-erly patients with chronic congestive heart failure(CHF).Methods Totally 60 elderly patients with chronic CHF were randomly divided into observation group and control group according to the order of admission,with 30 patients in each group.All patients received
conventional
therapy,
including
anti-heart
failure
drugs,cardiotonic drugs and diuretics.However,vasodilators were with-drawn and losartan potassium tablets were used in observation group 1 week before investigation. Plasma NT-proBNP levels were measured by colloidal
gold
immunoassay.The
changes
in
systolic
blood
pressure(SBP),diastolic blood pressure(DBP),heart
rate(HR),cardiothoracic ratio,NY-HA classⅡ-Ⅳ and plasma NT-proBNP levels were observed before and after treatment for 8 weeks.Results Compared with control group,losartan treatment decreased the SBP,DBP,HR, cardiothoracic ratio and plasma NT-proBNP levels and improved NYHA classⅡ,Ⅲ and Ⅳ after treatment for 8 weeks(P<0.05 or P<0.01).In addition,NYHA classⅡ,ⅢandⅣ were significantly improved
氯沙坦对老年慢性充血性心力衰竭患者血浆NT-proBNP水平的影响
