HDAC6与P21WAF1在胃癌组织中表达及意义
王秀茹;刘文天;张秋瓒;乔丽葵;张淑贤
【期刊名称】《中国肿瘤临床》 【年(卷),期】2012(039)001
【摘要】Objective: The current paper aims to investigate the HDAC6 and p21WAF1 expression, as well as their correlations, in gastric carcinoma and normal mucosa adjacent to carcinoma. The roles of these proteins in
gastric
carcinoma
were
also
investigated
Methods:
Immimohistocheniisiry was performed to detect the HDAC6 and p21WAF1 expression in 40 specimens of gastric carcinoma, 30 specimens of precancerous lesions ( chronic atrophic gastritis with intestinal metaplasia), and 32 specimens of normal mucosa adjacent to carcinoma. Resdts: The expression of HDAC6 in gastric carcinoma, precancerous lesions, and normal mucosa was 65.0%, 43.3%, and 12.5%, respectively. Meanwhile, the positive rates of p21WAF1 in gastric carcinoma, precancerous lesions, and normal mucosa were 45.0%, 63.3%, and 81.3%, respectively. A significant difference among the expression of HDAC6 and p21WAF1 in the three groups (P < 0.01) was observed In gastric carcinoma, the HDAC6 expression significantly increased in stage Ⅲ or Ⅳ tumors (P < 0.05), positive lymph-node metastasis, and poorly differentiated adenocarcinoma (P < 0.05 ). On the contrary, the p21WAF1 expression significantly decreased in stage
HDAC6与P21WAF1在胃癌组织中表达及意义
