1245株金黄色葡萄球菌临床感染分布及耐药性变迁
谢俊杰;孙恒彪;潘祖汉;尤旭;叶育华
【期刊名称】《中华实验和临床感染病杂志（电子版）》 【年(卷),期】2018(012)001
【摘要】目的 探讨临床分离的金黄色葡萄球菌的感染分布及耐药性变迁,为临床经验性用药及院内感染控制提供数据支持.方法 回顾调查分析本院2012年1月至2015年12月于住院部及门诊送检标本分离到的金黄色葡萄球菌耐药数据,使用Microscan Walkaway 40 Plus对金黄色葡萄球菌进行鉴定及抗菌药物敏感性试验,采用WHONET 5.6版本软件进行统计分析.结果 共分离1245株金黄色葡萄球菌,主要分离自患者痰液(565株,45.4%)、伤口分泌物(234株,18.8%)、脓液(136株,10.9%)和血液(89株,7.1%);检出657株耐甲氧西林金黄色葡萄球菌(MRSA),检出率为52.8%,其中,痰液中MRSA检出率最高(75.6%).金黄色葡萄球菌主要来源于神经外科(197株,15.8%)、ICU(172株,13.8%)、创伤骨科(161株,12.9%)和呼吸内科(132株,10.6%);神经外科以MRSA检出率最高(77.2%).金黄色葡萄球菌对利福平、复方新诺明、达托霉素、利奈唑胺、万古霉素和奎奴普丁/达福普汀敏感性较好,对青霉素类敏感性最差.MRSA仅对达托霉素、利奈唑胺、万古霉素和奎奴普丁/达福普汀敏感性较好,甲氧西林敏感金黄色葡萄球菌(MSSA)对常用抗菌药物除青霉素类以外的抗菌药物耐药率较低;MRSA对常用抗菌药物耐药率显著高于MSSA.结论 临床MRSA检出率较高,且对常用抗菌药物耐药形势严峻,临床科室经验用药同时应配合加强院内感染控制,预防及减少MRSA感染的发生.%Objective To investigate the infections distribution and changes of drug resistance of Staphylococcus aureus,
and provide reasonable using of antibiotics as to control infection in hospital. Methods The drug resistance data of Staphylococcus aureus isolated from inpatients and outpatients from January 2012 to December 2015 were collected. The data was analyzed by WHONET 5.6 software. Results Total of 1 245 strains of Staphylococcus aureus were isolated,
among
which,
657
strains
of
methicillin-resistant at
a
rate
with
Staphylococcus aureus(MRSA)were detected
52.8%.Among all strains,565 strains (45.4%) were isolated from sputum, 234 strains (18.8%) from wound secretion, 136 strains (10.9%) from pus, 89 strains(7.1%)from blood;and sputum had the highest detection rate of
MRSA.Staphylococcus
aureus
were
mainly
isolated
from
neurosurgery (197 strains, 15.8%), ICU (172 strains, 13.8%), orthopedic trauma (161 strains, 12.9%), and department of respiratory (132 strains, 10.6%);
the
highest
detection
rate
of was
MRSA
was
from to
neurosurgery.Staphylococcus aureus sensitive
rifampin,trimethoprim-sulfamethoxazole, daptomycin, linezolid and vancomycin, quinupristin/dalfopristin, while showed high resistance to penicillin antibiotic. MRSA maintained high sensitivity to daptomycin, linezolid, vancomycin and quinupristin/dalfopristin.The resistance rate of MRSA was higher than that of methicillin-sensitive Staphylococcus aureus (MSSA). Conclusions The detection rate of MRSA was high in hospital and the resistance rate of MRSA to common antibiotics were
serious. Clinical departments should make reasonable using of antibiotics and strengthen hospital infection control to decrease the incidence of MRSA infection. 【总页数】5页(89-93)
【关键词】金黄色葡萄球菌;耐甲氧西林金黄色葡萄球菌;耐药性;抗菌药物 【作者】谢俊杰;孙恒彪;潘祖汉;尤旭;叶育华
【作者单位】510630 广州市,南方医科大学第三附属医院检验科;510630 广州市,南方医科大学第三附属医院检验科;510630 广州市,南方医科大学第三附属医院检验科;510630 广州市,南方医科大学第三附属医院检验科;510630 广州市,南方医科大学第三附属医院检验科 【正文语种】中文 【中图分类】 【文献来源】
https://www.zhangqiaokeyan.com/academic-journal-cn_chinese-journal-experimental-clinical-infectious-diseases-electronic-edition_thesis/0201234685185.html 【相关文献】
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1245株金黄色葡萄球菌临床感染分布及耐药性变迁
