Up-regulation of carcinoembryonic antigen-related cell adhesion molecule 1 in gastrointest

Up-regulation of carcinoembryonic antigen-related cell adhesion molecule 1 in gastrointestinal cancer

and its clinical relevance

Muqing Zhou;Feng Gao;Manlin Cao;Zhiming Jin;Yiwen Liu;Yiqing He;Yan Du;Cuixia Yang;Yingzhi Wang;Jiajie Hu;Lian Cui

【期刊名称】《生物化学与生物物理学报：英文版》 【年(卷),期】2017(049)008

【摘要】Serum carcinoembryonic antigen-related cell adhesion molecule 1 (CEACAM1) is dysregulated in various malignant tumors and has been associated with tumor progression.However,the expression and regulatory mechanisms of serum CEACAM1 in gastrointestinal cancer are still unclear.The expression ratio ofthe CEACAM1-L and CEACAM1-S isoforms has seldom been investigated in gastrointestinal cancer.In this study,we intended to explore the expression and diagnostic value of CEACAM1 in gastrointestinal cancer.Serum CEACAM1 levels were measured by enzymelinked immunosorbent assay.The protein expression and distribution of CEACAM1 in tumors were examined by immunohistochemical staining.The expression patterns and ratio of CEACAM1-L/S were analyzed by reverse transcription-polymerase chain reaction.The results showed that serum CEACAM1 levels were significantly higher in cancer patients than in healthy controls.CEACAM1 was found in secreted forms within the

neoplastic glands,and its expression was more intense at the tumor invasion front.The CEACAM1-L/S (L:S) ratios were up-regulated during tumorigenesis.Our data suggest that the serum level of CEACAM1 may be used to discriminate gastrointestinal cancer patients from health controls.

【总页数】7页(737-743) 【关键词】

【作者】Muqing Zhou;Feng Gao;Manlin Cao;Zhiming Jin;Yiwen Liu;Yiqing He;Yan Du;Cuixia Yang;Yingzhi Wang;Jiajie Hu;Lian Cui

【作者单位】Department of Clinical Laboratory, Shanghai Jiao Tong University Affiliated Sixth People's Hospital, Shanghai 200233, China;Department of Clinical Laboratory, Shanghai Jiao Tong University Affiliated Sixth People's Hospital, Shanghai 200233, China;Department of Molecular Biology Laboratory, Shanghai Jiao Tong University Affiliated Sixth People's Hospital, Shanghai 200233, China;Department of Rehabilitation Medicine, Shanghai Jiao Tong University Affiliated Sixth People's Hospital, Shanghai 200233, China;Department of General Surgery, Shanghai Jiao Tong University Affiliated Sixth People's Hospital, Shanghai 200233, China;Department of Molecular Biology Laboratory, Shanghai Jiao Tong University Affiliated Sixth People's Hospital, Shanghai 200233, China;Department of Molecular Biology Laboratory, Shanghai Jiao Tong University Affiliated Sixth People's Hospital,

Shanghai 200233, China;Department of Molecular Biology Laboratory, Shanghai Jiao Tong University Affiliated Sixth People's Hospital, Shanghai 200233, China;Department of Molecular Biology Laboratory, Shanghai Jiao Tong University Affiliated Sixth People's Hospital, Shanghai 200233, China;Department of Clinical Laboratory, Shanghai Jiao Tong University Affiliated Sixth People's Hospital, Shanghai 200233, China;Department of Molecular Biology Laboratory, Shanghai Jiao Tong University Affiliated Sixth People's Hospital, Shanghai 200233, China;Department of Molecular Biology Laboratory, Shanghai Jiao Tong University Affiliated Sixth People's Hospital, Shanghai 200233, China 【正文语种】英文 【中图分类】 【文献来源】

https://www.zhangqiaokeyan.com/academic-journal-cn_acta-biochimica-biophysica-sinica_thesis/0201254939374.html 【相关文献】

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