新生儿医院获得性大肠埃希菌血流感染临床特征及耐药分
析
杨汉华;谢淑霞;温丽华;罗青苹;刘惠平
【期刊名称】《国际流行病学传染病学杂志》 【年(卷),期】2018(045)005
【摘要】Objective To analyze the clinical features and bacterial drug resistance of hospital-acquired Es-cherichia coli (E.coli) bloodstream infection in neonates. Methods From 2016 to 2017, 23 inpatients with hospi-tal-acquired E.coli bloodstream infection from Shenzhen University Maternal and Child Health Hospital and Gaozhou People's Hospital were studied. The basic disease, clinical characteristics, antibiotic resistance,outcomes and hos-pital costs were analyzed. Results Among the 23 cases, the most common symptom was fever (20 cases), fol-lowed by an elevating of blood glucose (>7 mmol/L,10 cases). There were 18 cases of respiratory system damage, including 10 cases of respiratory failure requiring ventilator-assisted ventilation and 2 cases of pulmonary hemor-rhage. Circulatory system damages were found in 5 cases. A total of 10 ESBLs-positive E. coli strains were checked out, and more than 80％ of which were resistant to ampicillin, ceftriaxone, cefepime, cefazolin, aztreonam and compound sulfamethoxazole. The resistant rates were all higher than those of ESBLs-negative E.coli strains (P<0.05). The hospitalization cost of ESBLs-positive strain infected
neonates was higher than that of the ESBLs-negative strains [(2.26±0.91)×104 yuan vs (1.68±0.83)×104 yuan, t=4.62, P<0.01]. Conclusions Fever and respiratory signs can be considered as early indications of hospital-acquired E.coli bloodstream infection in neonates. The resis-tant rate of ESBLs-positive E. coli strains is high, and the treament costs more.%目的 了解新生儿医院获得性大肠埃希菌血流感染的临床特点及细菌耐药性.方法选择2016—2017年深圳大学妇幼保健院和高州市人民医院诊断为获得性大肠埃希菌血流感染的住院新生儿共23例为研究对象,对患儿的临床特点、抗生素耐药情况、转归及住院费用等进行分析.结果23例患儿常见首发症状为发热(20例),其次为微量血糖升高(>7 mmol/L,10例);呼吸系统损害18例,其中10例发生呼吸衰竭需要呼吸机辅助通气,肺出血2例;循环系统损害5例.10株产ESBLs大肠埃希菌对氨苄西林、头孢曲松、头孢吡肟、头孢唑林、氨曲南、复方磺胺甲噁唑耐药率高于8/10,均高于ESBLs阴性大肠埃希菌(P<0.05).ESBLs阳性菌株感染新生儿的住院费用为(2.26±0.91)万元,显著高于阴性者的(1.68±0.83)万元,差异有统计学意义(t=4.62,P<0.01).结论发热、呼吸系统体征可作为发现新生儿大肠埃希菌血流感染的早期提示.ESBLs阳性大肠埃希菌感染耐药形势严峻,治疗费用更高. 【总页数】4页(305-308)
【关键词】婴儿;院内感染;大肠埃希菌;败血症 【作者】杨汉华;谢淑霞;温丽华;罗青苹;刘惠平
【作者单位】518122 广东省深圳市坪山区妇幼保健院 深圳大学妇幼保健院;525200 广东茂名,高州市人民医院新生儿科;518122 广东省深圳市坪山区妇
幼保健院 深圳大学妇幼保健院;518122 广东省深圳市坪山区妇幼保健院 深圳大学妇幼保健院;518122 广东省深圳市坪山区妇幼保健院 深圳大学妇幼保健院 【正文语种】中文 【中图分类】 【文献来源】
https://www.zhangqiaokeyan.com/academic-journal-cn_international-journal-epidemiology-infectious-disease_thesis/0201270340594.html 【相关文献】
1.社区获得性及医院获得性大肠埃希菌性尿路感染耐药情况分析 [J], 耿丽颖 2.社区获得性血流感染产 ESBLs 大肠埃希菌与肺炎克雷伯菌流行情况及危险因素初步分析 [J], 钟敏; 张凯; 黄湘宁; 殷琳; 刘鑫; 喻华; 黄文芳; 唐荣珍; 奉婷 3.大肠埃希菌与肺炎克雷伯菌血流感染的临床特征及耐药性比较 [J], 王莉洁; 梁志欣; 喻航; 吴珍; 陈良安
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5.大肠埃希菌与肺炎克雷伯菌血流感染的临床特征及耐药性比较 [J], 王莉洁 梁志欣 喻航 吴珍 陈良安
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新生儿医院获得性大肠埃希菌血流感染临床特征及耐药分析
