接触性热痛诱发电位对糖尿病小纤维神经病变的评价作用
张哲成;刘娜;邢国平;李斌
【期刊名称】《中华神经科杂志》 【年(卷),期】2008(041)010
【摘要】Objective To investigate a non-invasive and objective measure for patients with diabetic small fiber neuropathy by contact heat evoked potential (CHEP). Methods CHEP was performed in diabetic patients (n=46) and normal subjects (n =40). Thermal stimuli were given at 52 ℃ to 3 body sites: right forearm, right dersum hand and right peroneal area. CHEP were recorded from Cz. The main components of CHEP were observed. Studies on sensory nerve conduction were performed in all the diabetic patients and the normal subjects. Results In 7 patients there were no recordable CHEP on stimulation of the forearm, and in some cases of dorsum hand (n =9) and the leg (n = 16). In contrast, CHEP were recordable in all control subjects. The diabetic group had reduced N-P amplitudes and prolonged N-wave latencies. In patients with normal sensory nerve conductions, amplitudes of CHEP were reduced and latencies of CHEP were prolonged. Twenty-five patients had normal sensory nerve conduction for upper limbs, the amplitudes of CHEP being (34.0±12.6) μV vs (48.4±17.5)μN, Z= -3. 151, P<0.01 for the forearm, (28.2±10. 1) μV vs (43.0±16.6) μV, Z= -3.712, P<0.01 for the dersum hand with a latency of (420.4±27.8) ms vs (407.2±24.6) ms, t
接触性热痛诱发电位对糖尿病小纤维神经病变的评价作用
