5,10-亚甲基四氢叶酸还原酶基因多态性和叶酸摄人与先天
性心脏病的关系研究
李栋;景学安;王华义;叶文静;范华
【期刊名称】《中华预防医学杂志》 【年(卷),期】2009(043)008
【摘要】Objective To investigate the correlationship between congenital heart disease and 5,10-methylenetetra hydrofolate reductase (MTHFR)'s C677T or folacin intakes, and to study the interaction of them in the occurring of congenital heart disease. Methods We used case-control study (case=104, control=208) method. Cases and controls were chosen by age,sex and other conditions. The MTHFR C677T genotype distribution was analyzed by using polymerase chain reaction restricted fragment length polymorphism (PCR-RFLP) ,and non-conditional and multi-conditional logistic regression analysis were also used to analyze the correlationship and interaction of the factors. Results In case group, the number of people in low folacin intake level was 38(36. 54%) ,which in control group was 21 (10.10%). The intake level of folacin during pregnancy was related to congenital heart disease (X2=31.614, v=1, P<0.0001). The value of OR was 1. 417 with 95%CI 1.216-1.651 ,indicating that the low level of folacin intakes was a risk factor to the congenital heart disease. In case group,the number of TT genotype was 46 (44.24%) ,the number of CT genotype was 42 (40.38%) ,the
5,10-亚甲基四氢叶酸还原酶基因多态性和叶酸摄人与先天性心脏病的
