REG1a基因单核苷酸多态性与胃癌遗传易感性研究
李欣刚;刘晓光;裘云庆
【期刊名称】《浙江预防医学》 【年(卷),期】2009(021)003
【摘要】Objective Toinvestigate the association between genetic susceptibility of gastric carcinoma and single nucleotide polymorphism of REG1a gene in Chinese Han population. Methods The genotype of REG1a gene were detected by PCR and DNA sequencing in 183 Chinese patients with gastric carcinoma and 204 controls.Results It was found 3 new SNPs in REG1a gene at site 929(T/C),1790(C/G) and 2751(A/T), respectively; and the different genotypes of site 929 and 1790 were significant between gastric carcinoma patients and controls(P<0.05). Conclusions Sequencing of REG1a gene from specific population is available for screening candidate SNPs. The study reveals that the initially gastric carcinoma may be associated with site 929 and 1790. It provides a basis for further screening suitable SNPs labeling forecasting risk for gastric carcinoma.%目的 寻找中国汉族人群REG1a基因单核苷酸多态性位点,探讨其基因多态性与胃癌(Gastric Cancer)的关系.方法 应用PCR产物测序的方法在中国人群中检测散发性胃癌组(n=183)及对照组(n=204)REG1a
基因的单核苷酸多态性(single nucleotide
polymorphisms,SNPs).结果 REG1a基因第929位(T/C)、第1790位(C/G)、第2751位(A/T)发现3个新的SNP位点,其中第929位和第1790位2个位点
REG1a基因单核苷酸多态性与胃癌遗传易感性研究
