兔眼玻璃体腔注射抗血管内皮生长因子单克隆抗体
Bevacizumab的毒性观察
李筱荣;王艳辉;刘新玲;胡博杰
【期刊名称】《中华眼底病杂志》 【年(卷),期】2008(024)003
【摘要】Objective To observe the effects of structure and function of cornea,chamber angle and retina of varying doses of Bevacizumab which was injected intravitreally in rabbits. Methods Twenty-four New Zealand albino rabbits were divided into three groups randomly,the right eyes in three groups received intravitreal injection Avastin at dose 1.25 mg,2.5 mg and 5 mg respectively as experimental eye.the left eyes accepted intravitreal injection 0.9%normal saline at the same volume as a control eye.The anterior segment of eye and ocular fundus were examined and intraocular pressure was measured by slit-lamp microscope and direct ophthalmoscope before and after injection.It was tested by Electroretinogram(ERG)before and after injection 1,4,8 weeks.At the 8th week,it carried out corneal endothelium counting;then enucleated eyes tO observe by the light microscope and transmission electron microscope. Results No statistically significant difference regard to IOP,corneal endothelium counting,a-and b-waves of ERG at any stage of study in every group(P＞0.05).No obvious change at cornea,chamber angle.retinal structure and retinal uhrastructure in
兔眼玻璃体腔注射抗血管内皮生长因子单克隆抗体Bevacizumab的毒性观察
