Fern extracts potentiate fluconazole activity and inhibit morphological changes in Candida species
Fern extracts potentiate fluconazole activity and inhibit morphological changes in Candida species
Maria A.Freitas;Antonia T.L.Santos;Antonio J.T.Machado;Ana Raquel P.Silva;Fábia F.Campina;Maria S.Costa;Gioconda M.A.B.Martins;Maria Flaviana B.Morais-Braga;Saulo R.Tintino;Irwin
R.A.Menezes;Jaime
Ribeiro-Filho;Altevir
P.Medeiros;Adeliana
S.Oliveira;Patrício B.Maracajá;Henrique D.M.Coutinho;;;;;;;;;;;;;;;;;;;;;;;;;;;;;;;;;;;;;;;;;;;;;;
【期刊名称】《亚太热带生物医学杂志:英文版》 【年(卷),期】2017(000)011
【摘要】Objective: To investigate the antifungal activity of the fern species
Lygodium
venustum(L.
venustum)
and
Pityrogramma
calomelanos(P. calomelanos) against Candida albicans and Candida tropicalis strains.Methods: The microdilution method was used to evaluate the antifungal activity, as well as the modulating effects of ethanolic extracts of these plants in combination with fluconazole. The minimum
inhibitory
concentration(MIC),
minimum
fungicide
concentration and morphological changes were also determined.Results: The extract obtained from L. venustum presented a MIC > 8 192 mg/m L, while the extract obtained from and P. calomelanos presented a MIC = 8 192 mg/m L, indicating that they present weak antifungal activity. However, combination of the extracts with Fluconazole potentiated the antifungal activity of this drug. At different experimental conditions, such as concentration of the extract and type of strain, the extracts
Fern extracts potentiate fluconazole activity and inhibit morphological changes in Candida species
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