2型糖尿病家系一级亲属代谢综合征组分聚集情况及临床特
征分析
周慧;韦晓谋;周素娴;邓婷婷;韦卉;李锦华
【期刊名称】《中国社区医师》 【年(卷),期】2014(000)013
【摘要】Objective:To explore the component aggregation and clinical feature of metabolic syndrome in the first-degree relatives of type 2 diabetes pedigrees.Methods:We selected first-degree relatives of 41 type 2 diabetes pedigrees as study group(n=98),and we selected first-degree relatives without a family history of diabetes in their spouses as the control group(n=85).We measured some indexes,such as height,weight,waist
circumference,blood
pressure,fasting
blood
glucose,postprandial 2 hour blood glucose,triglyceride,high density lipoprotein,cholesterol.Non diabetic subjects underwent an oral glucose tolerance test.Study group was grouped according to the CDS standard in 2004:no abnormal metabolism group,with 1 metabolic abnormal group,with 2 abnormal metabolism,with MS group,with 1 or more abnormal metabolism group,with 2 or more abnormal metabolism group.We analyzed the component aggregation and clinical feature of the study groups,and compared with control group.Results:81.63% of the first-degree relatives of type 2 diabetes pedigrees had 1 or more MS component abnormity,50% had 2 or more MS component
abnormity,32.65% had MS,these were significantly higher than that of control group(the abnormal rate corresponding to the study group was 38.82%,29.41%,12.94% respectively)(P<0.01).Even before the occurrence of abnormal glucose metabolism,it can appear 1 or more components of MS anomaly.With the abnormal aggregation of MS component increased,blood glucose,waist circumference,SBP,DBP,TG were increased more
significantly,HDL-C
was
decreased
more
obviously(P<0.05).Conclusion:The first-degree relatives of type 2 diabetes pedigrees are more likely to occur in 1 or more abnormal of MS component compared with the general population,the crowd should be strengthened on the health education,and receive close monitoring of MS components and related metabolism indexes.%目的：分析2型糖尿病(T2DM)家系一级亲属同胞的代谢综合征(MS)各组分聚集情况及临床特征。方法：以41个T2DM家系中同胞一级亲属为研究组(n=98)，以同胞配偶中无糖尿病家族史的一级亲属同胞为对照组(n=85)。测定身高、腰围、体重、血压、空腹血糖、餐后2小时血糖、甘油三酯、高密度脂蛋白、胆固醇，非糖尿病者行口服葡萄糖耐量试验。其中研究组根据CDS在2004年的建议标准分为：无代谢异常组、伴1项代谢异常组、伴2项代谢异常组、伴MS组、伴1项以上代谢异常组、伴2项以上代谢异常组。对研究组的组分聚集情况及临床特征进行分析，并与对照组比较。结果：T2DM家系一级亲属同胞81.63%伴1项以上MS组分的异常，50%伴2项以上MS组分的异常，32.65%伴MS，显著高于对照组(对应的异常率分别为38.82%、29.41%、12.94%)(P＜
0.01)。在糖代谢异常发生前已可出现1项或多项MS组分异常。随MS组分异常聚集的增多，其血糖、腰围、SBP、DBP、TG升高越显著，HDL-C降低越明显(P＜0.05)。结论：T2DM家系一级亲属同胞比普通人群更容易发生MS组分中1项或多项异常，对这一人群应加强健康教育、密切监测MS组分及相关代谢指标。
【总页数】3页(34-35,38)
【关键词】2型糖尿病;代谢综合征;组分
【作者】周慧;韦晓谋;周素娴;邓婷婷;韦卉;李锦华
【作者单位】545005广西医科大学第四附属医院 柳州市工人医院内分泌科 广西柳州;545005广西医科大学第四附属医院 柳州市工人医院内分泌科 广西柳州;545005广西医科大学第四附属医院 柳州市工人医院内分泌科 广西柳州;545005广西医科大学第四附属医院 柳州市工人医院内分泌科 广西柳州;545005广西医科大学第四附属医院 柳州市工人医院内分泌科 广西柳州;545005广西医科大学第四附属医院 柳州市工人医院内分泌科 广西柳州 【正文语种】中文 【中图分类】 【文献来源】
https://www.zhangqiaokeyan.com/academic-journal-cn_chinese-community-doctors_thesis/0201214825267.html 【相关文献】
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2型糖尿病家系一级亲属代谢综合征组分聚集情况及临床特征分析
