Dietary habits, lifestyle factors and
neurodegenerative diseases
Aurel Popa-Wagner1, ＊, #, Dinu Iuliu Dumitrascu2, #, Bogdan Capitanescu3, Eugen Bogdan Petcu1, Roxana Surugiu4, Wen-Hui Fang5,Danut-Adrian Dumbrava4, ＊
【摘 要】Abstract Worldwide stroke is increasing in parallel with modernization, changes in lifestyle, and the growing elderly population. Our review is focused on the link between diet, as part of ‘modern lifestyle', and health in the context of genetic predisposition of individuals to ‘unhealthy' metabolic pathway activity. It is concluded that lifestyle including high sugar diets, alcohol and tobacco addiction or high fat diets as well as ageing,brain injury, oxidative stress and neuroinflammation, negatively influence the onset, severity and duration of neurodegenerative diseases. Fortunately, there are several healthy dietary components such as polyunsaturated fatty acids and the anti-oxidants
curcumin,
resveratrol,
blueberry
polyphenols,
sulphoraphane,salvionic acid as well as caloric restriction and physical activity,
which
may
counteract
ageing
and
associated
neurodegenerative diseases via increased autophagy or increased neurogenesis in the adult brain.
【期刊名称】《中国神经再生研究（英文版）》 【年(卷),期】2020(015)003
【总页数】7
【关键词】Key Words: brain injury; dietary habits; lifestyle; metaflammation; neurodegeneration; oxidative stress; type 2 diabetes mellitus REVIEw ＊
Correspondence
to:Aurel
Popa-Wagner,
PhD,aurel.popa-Dumbrava,
wagner@geriatrics-healthyageing.com;Danut-Adrian MD,danutdumbrava@gmail.com.
#Both authors contributed equally to this work. orcid:0000-0003-4574-8605(Aurel Popa-Wagner) Received: December 21, 2018 Accepted: June 20, 2019
Introduction
Worldwide stroke is increasing in parallel with modernization, changes in lifestyle, and the growing elderly population.Individuals with a healthy, low-risk lifestyle (no smoking,daily exercise, moderate alcohol consumption and having a moderate weight during their mid-forties) had a significantly lower risk of neurodegenerative diseases than the high-risk lifestyle group. Therefore, the relatively high incidence of neurodegenerative diseases may be due in part to the negative influence of daily risk factors including (Donnan et al.,2008): stress, lack of physical exercise, unhealthy nutrition,obesity, high cholesterol levels
in plasma, smoking, alcoholism or arterial hypertension.
Some intrinsic factors such as ageing, but also brain injury and associated exaggerated neuroinflammation, oxidative stress, as well as lifestyle factors including high sugar diets and high fat diets, alcohol and tobacco addiction, negatively influence neurodegeneration. But there are many components in our diet (polyunsaturated fatty acids, the antioxidants
curcumin,
resveratrol,
blueberry
polyphenols,sulphoraphane and salvionic acid) as well as caloric restriction, along with physical exercise that may allow us to live a healthier and longer life (Poulose et al., 2017). Although the progress of neurodegenerative diseases is, to some extent,measurable through anthropometric, lifestyle, and clinical factors, the mechanisms underlying neurodegenerative disease progression are not fully understood. The current review focuses on the link between lifestyle and health in the context of genetic predisposition of individuals to ‘unhealthy'metabolic pathway activities by performing a systematic literature search of the last 10 years. Data were from PubMed and Google Scholar.
Mechanisms Linking Lifestyle and Diet-Induced Metabolic Inflammation to Cerebrovascular Diseases
Fuelled by an increasingly sedentary lifestyle along with an unhealthy, “westernised” diet, the type 2 diabetes mellitus(T2DM) epidemic has
Dietary habits, lifestyle factors and neurodegenerative diseases
