An overview of the marine natural products in clinical trials and on the market

An overview of the marine natural products in

clinical trials and on the market

Marisa Rangel;Miriam Falkenberg

【期刊名称】《海岸生命医学杂志（英文版）》 【年(卷),期】2015(000)006

【摘要】The first marine natural products that served as leads or scaffolds for medicines were discovered in the middle of last century:the arabinosyl glycosides from the marine sponge Tectitethya crypta. Synthesis and modifications of the natural molecules generated antiviral and antileukemic drugs developed in the 1970’s and in the following decades, including the first effective treatment against HIV infection.
With the improvement of techniques for the elucidation of chemical structure of the molecules, as well as chemical synthesis, especially from the 1990’s, there was an increase in the number of bioactive natural products characterized from marine organisms. New chemical structures with high specificity towards molecular targets in cells allowed the development of new drugs with indication for the treatment of several illnesses, from cancer to new antibiotics, and even neurological disorders.
Currently there are at least 13 molecules derived from marine natural products on advanced clinical trials, and nine were approved to be used as medicines. Considering that in the past eight years, more than 1 000 new compounds from marine

organisms were described, per year, the expectation is that many more drugs will be derived from marine natural products in a near future. 【总页数】8页(421-428) 【关键词】

【作者】Marisa Rangel;Miriam Falkenberg

【作者单位】Immunopathology Laboratory, Division of Scientiifc Development,

Butantan

Institute,

05503-900,

Sao

Paulo,

Brazil;Department of Pharmaceutical Sciences, Federal University of Santa Catarina, 88040-970, Florianopolis, SC, Brazil 【正文语种】英文 【中图分类】 【文献来源】

https://www.zhangqiaokeyan.com/academic-journal-cn_coastal-life-medicine-journal-english_thesis/0201264246594.html 【相关文献】

1.Distribution and diversity of marine natural products from Indonesian marine organisms [J], MasteriaYunovilsa Putra; Tutik Murniasih

2.Natural herbal medicine Lianhuaqingwen capsule anti-influenza A （H1N1） trial： a randomized, double blind, positive controlled clinical trial [J], DUAN Zhong-ping; JIA Zhen-hua; ZHANG Jian; LIU Shuang; CHEN Yu; LIANG Lian-chun; ZHANG Chang-qing; ZHANG Zong; SUN Yan; ZHANG Shu-qin; WANG Yong-yan; WU Yi-ling

3.Immunotherapy for pancreatic ductal adenocarcinoma: an overview of clinical trials [J], Alessandro Paniccia; Justin Merkow; Barish H.Edil; Yuwen Zhu

4.Overview of clinical trials for nasopharyngeal carcinoma(in the English literature) [J], Anne W.M. Lee

5.Protective effect of natural products and hormones in colon cancer using metabolome:A physiological overview [J], Khaled Mohamed Mohamed Koriem

以上内容为文献基本信息，获取文献全文请下载