Synthesis, Characterization and Biological Activity of an Intramolecular Stacking Zinc(Ⅱ) Complex

Synthesis, Characterization and Biological Activity of an Intramolecular Stacking Zinc(Ⅱ) Complex

GAO, Enjun;LIU, Lei;ZHU, Mingchang;WU, Qiong

【期刊名称】《中国化学（英文版）》 【年(卷),期】2009(027)007

【摘要】The synthesis, crystallographic analysis and spectroscopic study of a zinc(Ⅱ) complex [Zn(bipy)(pmal)(H2O)]· 2H2O (bipy=2,2'-bipyfidine, pmal=phenylmalonic acid) were carded out. The complex has been investigated by the methods of X-ray crystallography, elemental analysis and IR spectra. The binding ability of the Zn(Ⅱ) complex to calf thymus (CT-DNA) was characterized by measuring the effects on the UV spectroscopy and fluorescence spectra of DNA. The agarose gel electrophoresis experimental results suggest that the ligand planaxity of complex has a significant effect on cleaving the pBR322 plasmid DNA. 【总页数】6页(1285-1290) 【关键词】

【作者】GAO, Enjun;LIU, Lei;ZHU, Mingchang;WU, Qiong

【作者单位】Laboratory of Coordination Chemistry, Shenyang Institute of Chemical Technology, Shenyang, Liaoning 110142, China;Laboratory of Coordination Chemistry, Shenyang Institute of Chemical Technology, Shenyang, Liaoning 110142, China;Laboratory of Coordination Chemistry, Shenyang Institute of Chemical Technology, Shenyang,