匹多莫德冲剂联合羧甲淀粉钠溶液治疗小儿反复呼吸道感
染的疗效及对患儿免疫功能的影响
戴丽凤;顾亮;陈淡璋;赖卫强
【期刊名称】《中国生化药物杂志》 【年(卷),期】2017(037)002
【摘要】Objective To investigate the effect of pidotimod granules and Carboxymethyl starch sodium solution in treating children with recurrent respiratory tract infection curative effect and effect on immune function of children.Methods 128 cases of children with recurrent respiratory tract infection in our hospital from June 2013 to June 2016 were selected and divided into treatment group and control group with 64 cases in each group. Children in the control group were treated with Carboxymethyl starch sodium solution, the treatment group was given pidotimod granules on the basis of the control group.Two groups of children were treated for 12 weeks.The therapeutic effects of the two groups were compared, the changes of immune function before and after treatment, cough, fever, lung rales disappear time, and the incidence of adverse reactions.Results The total effective rate of the treatment group (90.62%) was higher than the control group (75.00%), the difference was statistically significant (P<0.05), the levels of IgA, IgM and IgG increased after treatment in both groups, the levels of IgA, IgM and IgG in the treatment group were higher than those in
the control group, the difference was statistically significant (P<0.05), the levels of CD3 +, CD4 +and CD4 +/CD8 +increased after treatment in both groups, and the levels of CD3 +, CD4 +and CD4 +/CD8 +in the treatment group were higher than those in the control group, the difference was statistically significant (P<0.05), the treatment group in children with cough, fever, pulmonary rales disappeared faster than the control group, the difference was statistically significant (P <0.05), two groups were no obvious adverse reactions.Conclusion Pidotimod granules combined with carboxymethyl starch sodium solution in treating children with recurrent respiratory tract infections is effective, and could significantly improve the immune function of children.%目的 探讨匹多莫德冲剂联合羧甲淀粉钠溶液治疗小儿反复呼吸道感染疗效及对患儿免疫功能影响.方法 选取德清县人民医院及湖州市练市医院2013年6月~2016年6月期间收治的128例反复呼吸道感染患儿,按照随机数字表法分为治疗组与对照组,每组各64例.对照组患儿给予羧甲淀粉钠溶液治疗,治疗组在对照组基础上服用匹多莫德冲剂.2组患儿疗程均为12 w.比较2组患儿治疗疗效,治疗前后免疫功能水平变化,止咳、退热、肺部啰音消失时间,及不良反应发生情况.结果 治疗组总有效率(90.62%)高于对照组(75.00%),差异有统计学意义(P<0.05);2组患儿治疗后免疫球蛋白A(IgA)、免疫球蛋白M(IgM)及免疫球蛋白G(IgG)水平增加,治疗组患儿治疗后IgA、IgM及IgG水平高于对照组,差异有统计学意义(P<0.05);2组患儿治疗后CD3+、CD4+及CD4+/CD8+增加,治疗组患儿治疗后CD3+、CD4+及CD4+/CD8+高于对照组,差异有统计学意义(P<0.05);治
疗组患儿止咳、退热、肺部啰音消失时间快于对照组,差异有统计学意义(P<0.05);2组均未见明显不良反应发生.结论 匹多莫德冲剂联合羧甲淀粉钠溶液治疗小儿反复呼吸道感染疗效明显,且可明显改善患儿免疫功能. 【总页数】3页(279-281)
【关键词】匹多莫德冲剂;羧甲淀粉钠溶液;联合;小儿反复呼吸道感染;疗效;免疫功能
【作者】戴丽凤;顾亮;陈淡璋;赖卫强
【作者单位】德清县人民医院 儿科,浙江 湖州 313200;湖州市练市医院 儿科,浙江 湖州 313013;德清县人民医院 儿科,浙江 湖州 313200;台州市中心医院 检验科,浙江 台州 318000 【正文语种】中文 【中图分类】R714.253 【文献来源】
https://www.zhangqiaokeyan.com/academic-journal-cn_chinese-journal-biochemical-pharmaceuticals_thesis/0201242939610.html 【相关文献】
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匹多莫德冲剂联合羧甲淀粉钠溶液治疗小儿反复呼吸道感染的疗效及
