自体脐带血干细胞移植治疗神经母细胞瘤1例并文献复习
秦茂权;何柳;杨骏;周隨;王彬;朱光华;葛新顺;吴敏媛;冯涛
【期刊名称】《中国小儿血液与肿瘤杂志》 【年(卷),期】2014(000)004
【摘要】Objective High-dose chemotherapy combined with haemopoietic stem cell transplantation,mainly meant autologous peripheral blood stem cell transplantation,is an effective way to treat pediatric advanced stage solid tumor and to improve long term survival.Our group performed a stem cell transplantation using autologous cord blood on a neuroblastoma patient,and then combined with literature review to investigate the feasibility and efficacy of this procedure
on
neuroblastoma.
Methods
Before
the
transplantation,autologous cord blood sample was confirmed without neuroblast
which
expressed
CD45-/CD56+/CD81
+by
flow
cytometry.The preconditioning regimen of combination chemotherapy contains carboplatin,Etoposide ,Melphalan and so on.After the infusion of stem cell, acyclovir and gammaglobulin were administrated to prevent virus infection.Besides,the G-CSF is used to restore the number of neutrophil after 5 days of the transplantation.Results Twenty days after the transplantation,the number of WBC is 1 .8 ×109/L,the absolute number of neutrophil is over 0.5 × 109/L,31 days after the transplantation the number of platelets is 51 ×109/L,which meant this
patient′s haematogenesis has been restored.After 1 month of the transplantation,the levels of neuron-specific enolase (NSE)and urinary vanilly-mandelic acid (VMA)of 24th hours decreased to a normal range. Abdominal ultrasound and whole body PET-CT showed no mass found in the original site.So far up this patient had been 4 years and 8 months of disease-free survival by follow-up. Conclusions The autologous cord blood transplantation is an safe and effective way to treat advanced stage neuroblastoma, which can further develop the conservation value of autologous cord blood.%目的大剂量化疗联合造血干细胞移植是治疗小儿晚期实体肿瘤的重要方法，目前以自体外周血干细胞为主要干细胞来源，我院收治1例神经母细胞瘤（NB）患儿，对其行自体脐带血干细胞移植，结合文献复习探讨自体脐带血来源干细胞移植治疗NB的可行性及疗效。方法移植前脐血样本经流式细胞术检测，确认无CD45-/CD56＋/CD81＋表达的神经母细胞，采用含有卡铂、依托泊苷、马法兰等联合化疗的预处理办法，自体脐带血造血干细胞输注后予阿昔洛韦及丙种球蛋白预防病毒感染，移植＋5 d予G-CSF促进粒细胞恢复。结果患儿于移植＋20 d外周血白细胞数为1.8×109/L，中性粒细胞绝对值＞0.5×109/L，移植后＋31 d血小板51×109/L，造血恢复顺利。移植后1月复查血神经元特异性烯醇化酶、24 h尿香草扁桃酸降至正常，腹部超声及全身PET-CT提示肿瘤消失。随访至4年8个月，患儿无病生存。结论自体脐带血干细胞移植治疗晚期NB安全、有效，进一步提升自体脐带血的保存价值。
【总页数】4页(178-181)
【关键词】神经母细胞瘤;造血干细胞移植;自体脐带血移植 【作者】秦茂权;何柳;杨骏;周隨;王彬;朱光华;葛新顺;吴敏媛;冯涛
【作者单位】100045 北京，首都医科大学附属北京儿童医院血液病中心;636000 巴中，四川省巴中市人民医院儿科;100045 北京，首都医科大学附属北京儿童医院血液病中心;100045 北京，首都医科大学附属北京儿童医院血液病中心;100045 北京，首都医科大学附属北京儿童医院血液病中心;100045 北京，首都医科大学附属北京儿童医院血液病中心;100045 北京，首都医科大学附属北京儿童医院血液病中心;100045 北京，首都医科大学附属北京儿童医院血液病中心;100045 北京，首都医科大学附属北京儿童医院血液病中心 【正文语种】中文 【中图分类】 【文献来源】
https://www.zhangqiaokeyan.com/academic-journal-cn_journal-china-pediatric-blood-cancer_thesis/0201235892779.html 【相关文献】
1.1例神经母细胞瘤患儿脐带血造血干细胞移植术后的护理 [J], 罗媛媛; 束俊玫 2.强烈化疗和自体外周血造血干细胞移植及维甲酸治疗晚期神经母细胞瘤 [J], 唐锁勤; 黄东生; 王建文; 张晓飞; 刘立真; 于芳; 杨光
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自体脐带血干细胞移植治疗神经母细胞瘤1例并文献复习
