LRP 15基因在胃癌组织中的表达及临床意义
徐周敏;刘莉娜;裴峰;秦士新;吴俊兰
【期刊名称】《临床肿瘤学杂志》 【年(卷),期】2014(000)002
【摘要】Objective To investigate the expression of LRP15 gene in gastric cancer and its relationship with clinical features and prognosis. Methods The
expression
of
LRP15
gene
was
detected
using
immunohistochemistry in tissue microarrays containing 90 specimens of gastric cancer and paired adjacent normal mucosa tissues. Survival curves were plotted using Kaplan-Meier method, and Cox regression model to evaluate the independent prognostic factors. Results The LRP15 expression was lower in the tumor tissue compared with that in the adjacent normal mucosa tissue (0.563±0.046 vs. 0.822±0.054, P<0.001). According to the ratio of the expression of LRP15 in cancer tissues and that in adjacent tissues were divided into two groups:high-expression group ( ratio≥0.5, n=51) and low-expression group ( ratio<0.5, n=39) . LRP15 expression was statistically correlated with the tumor size ( P=0.038) and lymph node metastasis ( P=0.003) , but not with gender, age, tumor location, differentiation, tumor location, gross type, TNM stage and depth of invasion. The Kaplan-Meier method showed that patients with LRP15 low-expression had a significantly shorter medi-an overall survival compared with the patients with high-
LRP 15基因在胃癌组织中的表达及临床意义
