人纤维蛋白胶对大鼠肝损伤的止血护创作用
夏少晴;陈汉;仇毓东;薛毅
【期刊名称】《中国生化药物杂志》 【年(卷),期】2001(022)002
【摘要】Purpose The aim is to investigate the hemostatic and protective effect of fibrin sealant(FS) on liver trauma in rats.Methods On the surface of cracked wound(type Ⅰ) and resected wound(type Ⅱ)，spraying of FS or thrombin or direct suturation, was used receptively. Natural hemostasis was used as control.During postoperation the hemostatic time and the state of wound healing on 1st, 4th, 7th,14th, 50th day were observed.Results
Compared with the natural
hemostasis,the hemostatical time of the FS group was shorter 86.0%(P＜0.01)in liver trauma type Ⅰ and 79.0%(P＜0.01)in liver trauma type Ⅱ.Compared with the thrombin group,the hemostatical time of the FS group was shorten 45.0%(P＜0.01)in liver trauma type Ⅰ and 84.0%(P＜0.05) in liver trauma type Ⅱ.The wound surface of FS group was healed faster than that of other groups.Conclusion FS was an effective hemostatic and healing-promoter on liver trauma of rats.%目的探讨局部应用人纤维蛋白胶(FS)对实验性肝损伤的止血和护创作用。方法采用大鼠肝表面裂伤(Ⅰ型)和部分肝切除断面伤(Ⅱ型)模型，以自然止血法为阴性对照，缝合止血法和凝血酶止血法为阳性对照，比较各组间创面止血时间和术后d 1、4、7、14及50光镜下创面愈合情况。结果与自然止血组相比，FS组对Ⅰ型肝损
人纤维蛋白胶对大鼠肝损伤的止血护创作用
