儿童急性淋巴细胞白血病的长期随访和预后分析
陆海燕
【期刊名称】《中国实用医刊》 【年(卷),期】2024(045)011
【摘要】Objective To analyze treatment outcome and prognostic factors of children with a-cute lymphoblastic leukemia (ALL). Methods The clinical data and outcome of 176 pediatric ALL pa-tients were collected,the
clinical
characteristics,genetic
features,therapeutic
response,prognosis and prognostic factors were studied retrospectively. Univariate analysis and Log-rank test were used to analyze the prognostic factors. Results Among 176 patients,143 cases got complete induction therapy,com-plete remission rate was 95. 8％,and 5-year event free survival rate was 78. 2％ . Univariate analysis of prognostic factors:primary white blood cell (WBC)count ≥50 × 109 / L,age of onset ≥10-year old,T-ALL,had adverse reaction of prednisone,bone marrow in M2 / 3 stage after 15 days of induction,mini-mal residual disease (MRD)≥10 - 3 after 33 days of treatment,MRD≥10 - 4 after 3 months of treatment, BCR/ ABL gene positive and high-risk grade were related factors of poor prognosis. Multivariate COX re-gression analysis showed that T-ALL,bone marrow examination after 15 days of induction,MRD after 3 months of treatment,the risk grade were independent prognostic factors. Conclusions Children with ALL,especially non-high-risk
儿童急性淋巴细胞白血病的长期随访和预后分析
