Overexpression of SIRT1 is a poor prognostic factor for advanced colorectal cancer

Overexpression of SIRT1 is a poor prognostic

factor for advanced colorectal cancer

Jiang Kewei;Lyu Liang;Shen Zhanlong;Zhang Jizhun;Zhang Hui;Dong Jianqiang;Yan Yichao

【期刊名称】《中华医学杂志（英文版）》 【年(卷),期】2014(127)011

【摘要】Background Sirtuin 1 (SIRT1) has been reported to have diverse roles in various biological processes through deacetylation of histone and nonhistone proteins.However,the correlations among SIRT1 protein expression,clinicopathological parameters,and survival of colorectal cancer patients remain unclear.Methods SIRT1 protein expression was measured by immunohistochemistry in a paraffin-embedded tissue microarray,including 120 paired colorectal cancer and normal mucosa tissues.The

correlations

among features,and

SIRT1 prognosis

protein were

expression,clinicopathological

analyzed.Results All samples (100％) were positive for SIRT1,with variable staining in the cytoplasm rather than in the nucleus.There was significant

difference

in

SIRT1

overexpression

between

adenocarcinomas and normal mucosal tissue (P＜0.01,x2 test).SIRT1 overexpression was more frequently observed in advanced-stage tumors (P=0.046,0.002,x2test).SIRT1 overexpression was significantly correlated with poor overall survival (P=0.013,log-rank test) and