Observation on the Efficiency of the Mongolian Gerbil Kidney Tissue Culture Inactivated Bi

Observation on the Efficiency of the Mongolian Gerbil Kidney Tissue Culture Inactivated Bivalent

Vaccine for Hemorrhagic Fever with Renal

Syndrome

董关木;朱智勇;安祺;朱凤才;刘文雪;孔艳;杨立宏;俞永新

【期刊名称】《中华微生物学和免疫学：英文版》 【年(卷),期】2004(002)002

【摘要】The Z10 and Z37 strains of hemorrhagic fever with renal syndrome (HFRS) virus and the Mongolian gerbil (Merions unguiculatus ) kidney cells were used to prepare the inactivated bivalent vaccine. A phase Ⅱ clinical trial use of this vaccine was made in 750 Chinese volunteers. The results showed that the side reaction rate was 2.5% and the sero-conversion rate of neutralizing antibodies against Hantaan and Seoul viruses in the inoculated volunteers were 87.6% and 96.3% respectively.

【总页数】5页(115-119)

【关键词】肾出血热综合症;疫苗接种;小鼠;动物实验;免疫学 【作者】董关木;朱智勇;安祺;朱凤才;刘文雪;孔艳;杨立宏;俞永新 【

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CenterforDiseaseControlandPreventionofJiangsuProvence.Nanjing210009,China;CenterforDiseaseControlandPreventionofZhejiangProvence.Hang-