局部进展期直肠癌新辅助放化疗生存预后的相关因素分析
吴国举;余涛;贾文焯;安琪;肖刚;汪欣
【期刊名称】《中华医学杂志》 【年(卷),期】2017(097)010
【摘要】Objective To evaluate the clinical predictive factors for survival prognosis in patients with locally advanced rectal cancer after neoadjuvant chemoradiotheraphy.Methods The study included 87 patients with middle and lower locally advanced rectal cancer,who underwent neoadjuvant chemoradiotheraphy followed by radical surgery between April 2007 and May 2015.The clinical factors associated with 3-year disease-free survival (DFS) and overall survival (OS) were analyzed.Kaplan-Meier analysis of disease-free survival and overall survival was performed for all patients.Results The 3-year DFS was significantly improved in patients with negative lymph node (95.2％ vs 69.5％,x2 =8.642,P=0.003).The 3-year OS was better in the patients with lower serum level of pre-chemoradiotheraphy carcinoembryonic antigen (CEA) (90.9％ vs 66.7％,x2 =8.820,P =0.003).Cox regression multivariate
analysis
revealed
that
serum
level
of
pre-
chemoradiotheraphy CEA was an independent predictive factor for 3-year OS (P =0.035).Conclusion Serum level of pre-chemoradiotheraphy CEA is an independent risk factor for 3-year OS.%目的 探索影响局部进展期直肠癌新辅助放化疗后生存预后的临床影响因素.方法 回顾性分析2007年4
局部进展期直肠癌新辅助放化疗生存预后的相关因素分析
