Efficacy and Safety of Esmolol in Treatment of
Patients with Septic Shock
Wei Du;Xiao-Ting Wang;Yun Long;Da-Wei Liu
【期刊名称】《中华医学杂志（英文版）》 【年(卷),期】2016(129)014
【摘要】Background:Previous studies have suggested that β1-receptor blockers benefit septic shock patients.This study aimed to determine whether β1-receptor blockers benefit tissue perfusion in sepsis and to identify
parameters
to
reduce
the
risk
of
this
drug
in
sepsis.Methods:Consecutive septic shock patients were recruited from the Intensive Care Unit of Peking Union Medical College Hospital within 48 h of diagnosis.All patients were hemodynamically stable and satisfactorily sedated with a heart rate (HR) ≥100 beats/min.Esmolol therapy achieved the target HR of 10-15％ lower than the baseline HR.Clinical and physiological data of patients were collected prospectively within 1 h prior to esmolol therapy and 2 h after achieving the targeted HR.Results:Sixty-three patients were recruited.After esmolol therapy,blood pressure was unaltered,whereas stroke volume (SV) was increased compared with before esmolol therapy (43.6 ± 22.7 vs.49.9 ± 23.7 ml,t =-2.3,P =0.047).Tissue perfusion,including lactate levels (1.4 ± 0.8 vs.1.1 ± 0.6 mmol/L,t =2.6,P =0.015) and the central venous-to-arterial carbon dioxide difference (5.6 ± 3.3 vs.4.3 ± 2.2
Efficacy and Safety of Esmolol in Treatment of Patients with Septic Shock
