多体素1H-MRS对经导管肝动脉化疗栓塞联合内皮抑制素
治疗兔VX2肝移植瘤的动态随访研究
李海庆;孙业全;张新炎;焦自梅;王锡臻;王滨
【期刊名称】《实用放射学杂志》 【年(卷),期】2011(027)012
【摘要】Objective To explore the value of multi-voxel ] H-MRS in the evaluation of the effect of combination of transcathctcr arterial chcmocmbolization (TACK!) and endostatin (ES) on VX2 carcinoma implanted in rabbit liver. Methods Twenty-four VX2 liver tumor models were established and randomly divided into three groups. Planar sonography was applied to detect the growth of the tumor. When the tumor volume was 1 cm' , the following preplanned interference was started: normal saline ( lOml/d, 9d) was administered via marginal car vein of the rabbits in the control group (Group A, n = 8) ; lipiodol (0. 2 ml/kg) and adramycin (ADM,2 mg/kg) were administered via hepatic artery, as well as ES (0. 7 mg ? Kg ] ? D ] ,9d) via marginal car vein in Group B (n = 8) ; ES (0. 7 mg ? Kg~] ? D ] , 9d) was administered via marginal car vein in group C (n -8). Ti Wl, I % Wl and multi-voxel 1 H-MRS were performed one day before the interference and 3 , 6 , 9 days after the interference. The imaging characteristics andthe dynamic changes of the metabolic index of the tumors detected by multiple-voxel 1 H-MRS at different time points were observed and analyzed.
多体素1H-MRS对经导管肝动脉化疗栓塞联合内皮抑制素治疗兔VX2肝移植
