耐碳青霉烯类铜绿假单胞菌的产酶及联合药敏试验
叶明;杨喜民;王刚;雷光文
【期刊名称】《东南国防医药》 【年(卷),期】2011(013)002
【摘要】Objective To analyze the zymogenic state and antimicrobial agent combination activity in vitro test of Carbapenems-resistant Pseudomonas aeruginosa ( CR-PA), in order to provide laboratory data for clinical treatment. Methods All strains were isolated and identified by routine procedure and VITEK-Compact 2 automatic bacterial identification system. Routine antimicrobial susceptibility tests were performed with K-B method and MICa were detected with agar dilution method according to CLSI. Results There were 190 strains Pseudomonas aernginosa isolated from clinical infectious specimen. CR-PA was 9.47％ in all of that came from respiratory tract specimen. There were 10 strains produced Metallo-β-lactmases and AmpC, 4 strains produced Metallo-β-lactmases. The synergy rate of Cefpirome, Cefoperazone/Sulbactam, Imipenem plus Amikaein were 33.3％, 61.1％, and 27.8％ respectively. Conclusion CR-PA mostly came from respiratory tract specimen.The zymogenic rates and drug resistance of CR-PA were high, mostly due to multiplex drug-resistance mechanism. Clinical treatment should first select enzyme-inhibitory drugs ( Piperacillin/Tasobactam or Cefoperazone/sulbactam) combined with
耐碳青霉烯类铜绿假单胞菌的产酶及联合药敏试验
