Reflection-mode photoacoustic microscopy using a hollow focused ultrasound transducer for

Reflection-mode photoacoustic microscopy using a hollow focused ultrasound transducer for in vivo

imaging of blood vessels

Yuan Yi;Yang Si-Hua

【期刊名称】《中国物理：英文版》 【年(卷),期】2012(021)005

【摘要】A reflection-mode photoacoustic microscope using a hollow focused ultrasound transducer is developed for highresolution in vivo imaging.A confocal structure of the laser and the ultrasound is used to improve the system resolution.The axial and lateral resolutions of the system are measured to be～32 μm and～58 μm,respectively.Ex vivo and in vivo modes are tested to validate the imaging capability of the photoacoustic microscope.The adjacent vein and artery can be seen clearly from the reconstructed photoacoustic images.The results demonstrate that the reflectionmode photoacoustic microscope can be used for high-resolution imaging of micro-blood vessels,which would be of great benefit for monitoring the neovascularization in tumor angiogenesis.

【总页数】5页(283-287) 【关键词】

【作者】Yuan Yi;Yang Si-Hua

【作者单位】MOE Key Laboratory of Laser Life Science & Institute of