乙醛脱氢酶1与乳腺癌的分子亚型和临床病理特征的相关
性
周文辉;易晓雷;唐中华
【期刊名称】《肿瘤药学》 【年(卷),期】2014(000)006
【摘要】目的：探讨乙醛脱氢酶1（ALDH1）在乳腺癌中的表达及其与乳腺癌分子亚型和临床病理特征的相关性。方法应用免疫组织化学方法检测和比较20例乳腺癌癌旁正常乳腺组织、20例良性乳腺肿瘤组织及80例乳腺浸润性导管癌组织（Luminal A型、Luminal B型、Her-2过表达型、Basal-like型各20例）中ALDH1的表达情况，统计分析乳腺癌组织中ALDH1的表达与其分子亚型和临床病理特征的相关性。结果在20例乳腺癌癌旁正常乳腺组织及20例良性乳腺肿瘤组织中，ALDH1均呈阴性表达；80例乳腺浸润性导管癌组织中，ALDH1呈阳性表达者17例（21.25％），阳性表达率显著高于乳腺癌癌旁正常乳腺组织及良性乳腺肿瘤组织（P<0.05）；不同分子亚型乳腺癌组织中ALDH1的阳性表达率有显著性差异（P<0.05），高表达于Basal-like型及Her-2过表达型，低表达于Luminal型，且Basal-like型与Luminal型乳腺癌组织中ALDH1的阳性表达率比较有显著性差异（P<0.007），其它两两组间比较均未见显著性差异（P>0.007）。ALDH1的阳性表达与乳腺癌患者的年龄、肿瘤大小、临床分期、淋巴结转移、CK5/6、TopⅡ、Ki-67表达均无关，与ER、PR状态具有显著相关性（P<0.01）。结论乳腺癌组织中，ALDH1呈阳性表达，与乳腺癌的发生和分子分型有关，可能有助于乳腺癌的诊断、分型及预后预测。%Objective To study the expression of ALDH1 in breast cancer and
the relationship between ALDH1 and molecular subtypes and clinicopathological features of breast cancer. Methods Immunohemistry (IHC) was used to detect the expression of ALDH1 in 20 cases of tumor adjacent normal breast tissues, 20 cases of benign breast tumor tissues and 80 cases of invasive ductal carcinoma tissues, including Luminal A subtype, Luminal B subtype, Her-2 over-expression subtype and Basallike subtype, 20 cases of each subtype. The correlation of ALDH1 expression with the molecular subtypes and clinicopathological features of breast cancer were analyzed. Results The ALDH1 was negatively expressed in 20 cases of tumor-adjacent normal breast tissues and 20 cases of benign breast tumor tissues. 17 cases of invasive ductal carcinoma cases had positive expression of ALDH1, accounting for 21.25%. The positive expression rate of ALDH1 in carcinoma tissues was significantly higher than that of the tumor-adjacent normal breast tissues or benign breast tumor tissues (P<0.05). Moreover, the ALDH1 positive expression rate was significantly different between different molecular subtypes of breast cancer tissues (P<0.05). ALDH1 was highly expressed in Basal-like subtype and Her-2 over-expression subtype, but weakly expressed in Luminal subtype. Pairwise comparisons showed no significant difference in the ALDH1 positive expression rate between these subtype groups, except Basal-like and Luminal (P<0.007,α=0.007). In addition, the positive expression of ALDH1 had no significant
correlation with the clinical and pathological features of breast cancer, includ-ing age, tumor size, clinical stage, lymph node metastasis, CK5/6, TopⅡ, Ki-67, but was significantly related to ER and PR levels (P<0.01). Conclusion ALDH1 positive phenotype only expressed in breast cancer, and was related to the development and molecular subtypes of breast cancer. It may contribute to the diagnosis, subtyping and prognostic prediction of breast cancer. 【总页数】7页(419-425)
【关键词】乙醛脱氢酶1;乳腺癌;分子亚型;雌激素受体;雄激素受体 【作者】周文辉;易晓雷;唐中华
【作者单位】长沙市第八医院胃肠乳甲外科，湖南长沙，410100;长沙市第八医院胃肠乳甲外科，湖南长沙，410100;中南大学湘雅附二医院乳腺甲状腺科，湖南长沙，410011 【正文语种】中文 【中图分类】R737.9 【文献来源】
https://www.zhangqiaokeyan.com/academic-journal-cn_anti-tumor-pharmacy_thesis/0201237096532.html 【相关文献】
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乙醛脱氢酶1与乳腺癌的分子亚型和临床病理特征的相关性
