Product Data?SheetMyriocinCat. No.:CAS No.:分?式:分?量:作?靶点:作?通路:储存?式:HY-N679835891-70-4C??H??NO?401.54HCVAnti-infectionPowderIn solvent-20°C-80°C-20°C3 years6 months1 monthInhibitors?Agonists?Screening Libraries溶解性数据体外实验DMSO : 5 mg/mL (12.45 mM; ultrasonic and warming and heat to 60°C)Mass1 mg5 mg10 mgSolventConcentration制备储备液1 mM5 mM10 mM2.4904 mL0.4981 mL0.2490 mL12.4521 mL2.4904 mL1.2452 mL24.9041 mL4.9808 mL2.4904 mL请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；?旦配成溶液，请分装保存，避免反复冻融造成的产品失效。储备液的保存?式和期限：-80°C, 6 months; -20°C, 1 month。-80°C 储存时，请在 6 个?内使?，-20°C 储存时，请在 1 个?内使?。体内实验请根据您的实验动物和给药?式选择适当的溶解?案。以下溶解?案都请先按照 In Vitro ?式配制澄清的储备液，再依次添加助溶剂： 为保证实验结果的可靠性，澄清的储备液可以根据储存条件，适当保存；体内实验的?作液，建议您现?现配，当天使?； 以下溶剂前显?的百分?是指该溶剂在您配制终溶液中的体积占?；如在配制过程中出现沉淀、析出现象，可以通过加热和/或超声的?式助溶1. 请依序添加每种溶剂：?50% PEG300 ?? 50% salineSolubility: 5 mg/mL (12.45 mM); Suspended solution; Need ultrasonicBIOLOGICAL ACTIVITY?物活性Myriocin 是?种从 Myriococcum albomyces, Isaria sinclairi 和 Mycelia sterilia 中分离的真菌代谢产物，是?种有效的丝氨酸-棕榈酰转移酶 (serine-palmitoyl-transferase) 抑制剂，是鞘脂从头合成的关键。Myriocin 强烈抑制亚基因组 HCV-1b 复制?和基因型 2a 感染性 HCV 的 JFH-1 株的复制，抑制 HCV 感染的 IC50 为 3.5 μg/mL。Page 1 of 2 www.MedChemExpress.cn
IC?? & Target
Serine-palmitoyl-transferase (SPT)[1]
REFERENCES
[1].?He Q, et al. Inhibition of serine palmitoyltransferase by myriocin, a natural mycotoxin, causes inductionof c-myc in mouse liver. Mycopathologia. 2004 Apr;157(3):339-47.
[2].?Amemiya F, et al. Targeting lipid metabolism in the treatment of hepatitis C virus infection. J Infect Dis. 2008 Feb 1;197(3):361-70.
[3].?Ciesek S, et al. The suppressive effect that myriocin has on hepatitis C virus RNA replication is independent of inhibition of serine palmitoyl transferase. J Infect Dis. 2008 Oct 1;198(7):1091-3.
McePdfHeightCaution: Product has not been fully validated for medical applications. For research use only.
Tel: 400-820-3792; 021-58955995 Fax: 021-53700325 E-mail: tech@MedChemExpress.cn
Master of Small Molecules — 您?边的抑制剂?师
Page 2 of 2 www.MedChemExpress.cn
多球壳菌素作用机制- Medchemexpress- MCE中国
