基质细胞衍生因子-1及其受体在造血调控中的作用
傅晋翔;张学光
【期刊名称】《中国医学科学院学报》 【年(卷),期】2001(023)002
【摘要】Hematopoietic stem/progenitor cell transplantation is one of main choices for treating patients with malignant tumor or heredity diseases in recently year. The homing of hematopoietic stem cells(HSC) is a committed step to ensure the bone marrow hematopoiesis reconstitution. Recent studies have showed that stromal cell derived factor-1 (SDF-1) and its receptor has important effects on proliferation, differentiation, homing of HSC to bone marrow and hematopoiesis reconstitution. The purpose of this review is to give a recent update informations on mechanism of hematopoiesis regulation mediated by SDF-1 and its receptor%造血干/祖细胞(HSC)移植是目前治疗多种恶性肿瘤及遗传性疾病的主要方法,而HSC归巢骨髓的能力则决定了移植的成功与否。目前的研究证实,基质细胞衍生因子-1(SDF-1)及其受体(CXCR4)在HSC增殖、分化及促进其归巢骨髓,重建造血功能中发挥着重要作用。本文就SDF-1在造血调控中的作用及其机制作一综述。 【总页数】5页(184-188)
【关键词】基质细胞衍生因子归巢造血调控 【作者】傅晋翔;张学光
【作者单位】苏州大学生物技术研究所免疫研究室,;苏州大学生物技术研究所免
基质细胞衍生因子-1及其受体在造血调控中的作用
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